U.S.-Korea Cooperative Science: Parrel Model Studies for Cytochrome P-450 and Methane Monooxygenase.

9982088QueThis award supports a 2 years collaborative research project between Dr. Lawrence Que，University of Minnesota - Twin Cities and Professor Wonwoo Nam，EWHA Womans' University，Korea. 拟议的合作重点是合成血红素和非血红素铁复合物作为其生物类似物的模型的机理研究。 结合南教授在血红素络合物方面的专业知识和阙博士在非血红素络合物方面的专业知识，合作者将比较和对比血红素和非血红素铁催化剂在烃氧化中的反应性。合作项目包括两个部分。 第一部分为铁系催化剂上烷烃羟基化和烯烃沉积反应的机理研究。在不同的反应条件下，如溶剂和氧化剂的血红素和非血红素铁配合物的反应性进行了比较。 该项目的第二部分是反应中间体的光谱表征，当它们在反应过程中被识别时。 中间体的反应性和光谱性质的相关性将为血红素和非血红素化学中的酶促反应机制提供有价值的信息。该项目将与韩国EWHA女子大学的Wonwoo Nam教授一起在美国-韩国合作科学计划。 该项目与美国的目标有关-韩国合作科学计划，旨在通过科学信息、思想、技能和技术的交流，以及通过在互利问题上的合作，提高美国和韩国科学家和工程师之间的合作水平。 韩国的参与得到了韩国科学与工程基金会（KOSEF）的支持。

9982088QueThis award supports a 2-year collaborative research project between Dr. Lawrence Que, University of Minnesota - Twin Cities and Professor Wonwoo Nam, EWHA Womans' University, Korea. The proposed collaboration focuses on mechanistic studies on synthetic heme and nonheme iron complexes as models for their biological analogs. Combining the expertise of Professor Nam on heme complexes and Dr. Que on nonheme complexes, the collaborators will compare and contrast the reactivities of heme and nonheme iron catalysts in hydrocarbon oxidations.The cooperative project comprises of two parts. The first part consists of mechanistic studies on alkane hydroxylation and alkene eposidation by iron catalysts. The reactivity of heme and nonheme iron complexes will be compared under various reaction conditions such as solvent and oxidant. The second part of the project is the spectroscopic characterization of reaction intermediates when they are identified during the reaction. The correlation of the reactivity and the spectroscopic properties of the intermediates will provide valuable information for the mechanisms of the enzymatic reactions in both the heme and the nonheme chemistry.This project will be performed in conjunction with Professor Wonwoo Nam, EWHA Womans' University, Korea under the U.S.-Korea Cooperative Science Program. This project is relevant to the objectives of the U.S.-Korea Cooperative Science Program, which seeks to increase the level of cooperation between U.S. and Korean scientists and engineers through the exchange of scientific information, ideas, skills, and techniques and through collaboration on problems of mutual benefit. Korean participation is supported by the Korea Science and Engineering Foundation (KOSEF).