U.S.-Korea Cooperative Science: Parrel Model Studies for Cytochrome P-450 and Methane Monooxygenase.

9982088该奖项支持明尼苏达大学双子城分校的Lawrence Que博士和韩国EWHA女子大学的Wonwoo South教授之间为期两年的合作研究项目。拟议的合作重点是对合成的血红素和非血红素铁络合物进行机制研究，作为其生物类似物的模型。结合南教授在血红素络合物方面的专长和QUE博士在非血红素络合物方面的专业知识，合作者将比较和对比血红素和非血红素铁催化剂在碳氢化合物氧化中的反应活性。合作项目包括两部分。第一部分是铁催化烷烃羟基化和烯烃环氧化反应的机理研究。在不同的反应条件下，如溶剂和氧化剂，将比较血红素和非血红素铁络合物的反应活性。该项目的第二部分是在反应过程中确定反应中间体时对它们的光谱表征。中间体的反应性和光谱性质的相关性将为血红素和非血红素化学中的酶反应机理提供有价值的信息。该项目将与韩国EWHA女子大学的南元宇教授在美韩合作科学计划下进行。该项目与美韩合作科学计划的目标相关，该计划旨在通过交流科学信息、想法、技能和技术以及通过在互利问题上的合作来提高美国和韩国科学家和工程师之间的合作水平。韩国的参与得到了韩国科学与工程基金会(KOSEF)的支持。

9982088QueThis award supports a 2-year collaborative research project between Dr. Lawrence Que, University of Minnesota - Twin Cities and Professor Wonwoo Nam, EWHA Womans' University, Korea. The proposed collaboration focuses on mechanistic studies on synthetic heme and nonheme iron complexes as models for their biological analogs. Combining the expertise of Professor Nam on heme complexes and Dr. Que on nonheme complexes, the collaborators will compare and contrast the reactivities of heme and nonheme iron catalysts in hydrocarbon oxidations.The cooperative project comprises of two parts. The first part consists of mechanistic studies on alkane hydroxylation and alkene eposidation by iron catalysts. The reactivity of heme and nonheme iron complexes will be compared under various reaction conditions such as solvent and oxidant. The second part of the project is the spectroscopic characterization of reaction intermediates when they are identified during the reaction. The correlation of the reactivity and the spectroscopic properties of the intermediates will provide valuable information for the mechanisms of the enzymatic reactions in both the heme and the nonheme chemistry.This project will be performed in conjunction with Professor Wonwoo Nam, EWHA Womans' University, Korea under the U.S.-Korea Cooperative Science Program. This project is relevant to the objectives of the U.S.-Korea Cooperative Science Program, which seeks to increase the level of cooperation between U.S. and Korean scientists and engineers through the exchange of scientific information, ideas, skills, and techniques and through collaboration on problems of mutual benefit. Korean participation is supported by the Korea Science and Engineering Foundation (KOSEF).