U.S.-Korea Cooperative Science: Parrel Model Studies for Cytochrome P-450 and Methane Monooxygenase.

9982088该奖项支持明尼苏达大学双城分校Lawrence Que博士和韩国梨花女子大学Wonwoo Nam教授为期两年的合作研究项目。拟议的合作侧重于合成血红素和非血红素铁配合物的机制研究，作为其生物类似物的模型。结合南教授在血红素配合物方面的专业知识和柯博士在非血红素配合物方面的专业知识，合作者将比较和对比血红素和非血红素铁催化剂在碳氢化合物氧化中的反应活性。合作项目由两部分组成。第一部分是铁催化剂催化烷烃羟基化和烯烃环氧化的机理研究。比较了血红素和非血红素铁配合物在溶剂和氧化剂等不同反应条件下的反应活性。该项目的第二部分是在反应过程中识别反应中间体时对其进行光谱表征。中间体的反应活性与光谱性质的相关性将为血红素和非血红素化学中酶促反应的机理提供有价值的信息。该项目将与韩国梨花女子大学教授南元宇（音译）共同进行，隶属于韩美合作科学项目。该项目与美韩合作科学项目（U.S.- korea Cooperative Science Program）的目标相关，该项目旨在通过科学信息、思想、技能和技术的交流以及在互利问题上的合作，提高美韩科学家和工程师之间的合作水平。韩国的参与得到了韩国科学工程财团（KOSEF）的支持。

9982088QueThis award supports a 2-year collaborative research project between Dr. Lawrence Que, University of Minnesota - Twin Cities and Professor Wonwoo Nam, EWHA Womans' University, Korea. The proposed collaboration focuses on mechanistic studies on synthetic heme and nonheme iron complexes as models for their biological analogs. Combining the expertise of Professor Nam on heme complexes and Dr. Que on nonheme complexes, the collaborators will compare and contrast the reactivities of heme and nonheme iron catalysts in hydrocarbon oxidations.The cooperative project comprises of two parts. The first part consists of mechanistic studies on alkane hydroxylation and alkene eposidation by iron catalysts. The reactivity of heme and nonheme iron complexes will be compared under various reaction conditions such as solvent and oxidant. The second part of the project is the spectroscopic characterization of reaction intermediates when they are identified during the reaction. The correlation of the reactivity and the spectroscopic properties of the intermediates will provide valuable information for the mechanisms of the enzymatic reactions in both the heme and the nonheme chemistry.This project will be performed in conjunction with Professor Wonwoo Nam, EWHA Womans' University, Korea under the U.S.-Korea Cooperative Science Program. This project is relevant to the objectives of the U.S.-Korea Cooperative Science Program, which seeks to increase the level of cooperation between U.S. and Korean scientists and engineers through the exchange of scientific information, ideas, skills, and techniques and through collaboration on problems of mutual benefit. Korean participation is supported by the Korea Science and Engineering Foundation (KOSEF).