Biomimetic Synthesis of Fused Polycyclic Ethers

稠合多环醚的仿生合成

• 批准号: 9982400
• 负责人: Frank McDonald
• 金额: $ 36.6万
• 依托单位: Emory University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-01 至 2003-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9982400&HistoricalAwards=false
• 关键词: Biomimetic; Synthesis; Fused; Polycyclic; Ethers

The focus of this research is the mimicing of biological pathways to prepare a variety of polycyclic ether natural products. The project will develop methodology for the tandem endo-selective oxacyclizations of multiple cyclic sulfates; tandem endo-oxacyclizations of polyepoxides, including studies of substituent effects, electrophilic activating agents and other oxacyclic nucleophiles; and the biomimetic synthesis of hemibrevetoxin B from tandem oxidative cyclization of an acyclic prehemibevetoxin polyene precursor.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Frank E. McDonald of the Department of Chemistry at Emory University. Professor McDonald will focus his work on developing novel strategies for the biomimetic synthesis of trans-syn-trans fused polycyclic ethers. This structural motif is found in many marine natural products that have important and interesting biological properties.

本研究的重点是模拟生物途径来制备多种多环醚天然产物。该项目将开发多种环状硫酸酯的串联内选择性氧杂环化方法；聚环氧化物的串联内氧环化，包括取代基效应、亲电子活化剂和其他氧环亲核试剂的研究；有机和高分子化学项目通过该奖项支持埃默里大学化学系 Frank E. McDonald 博士的研究。 McDonald教授的工作重点是开发仿生合成反式-顺式-反式稠合多环醚的新策略。 这种结构基序存在于许多具有重要且有趣的生物学特性的海洋天然产物中。