Synthesis of Polycyclic Ethers via Alkynol Cycloisomerization

炔醇环异构化合成多环醚

• 批准号: 9501608
• 负责人: Frank McDonald
• 金额: $ 19.2万
• 依托单位: Northwestern University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-04-15 至 1999-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9501608&HistoricalAwards=false
• 关键词: Synthesis; Polycyclic; Ethers; via; Alkynol

The focus of this research is the development of the transition metal-catalyzed cyclization of alkynols to afford isomeric endocyclic enol ethers. The methodology represents a key step in the projected synthesis of two bioactive ionophores, routiennocin and calcimycin. The focus of the educational plan involves the teaching of chemistry by encouraging the use of inductive reasoning skills. With this CAREER award, the Synthetic Organic Program is supporting the research and educational plan of Dr. Frank E. McDonald of the Department of Chemistry at Northwestern University. Professor McDonald will focus his research efforts on the development of new methods for the synthesis of polyether natural products, compounds posessing important biological properties. The focus of Processor McDonald's educational plan involves the teaching of chemistry by encouraging the use of inductive reasoning skills.

本研究的重点是开发过渡金属催化的炔醇环化以提供异构的环内烯醇醚。 该方法代表了预计合成两种生物活性离子载体鲁替诺星和钙霉素的关键步骤。教育计划的重点是通过鼓励使用归纳推理技能来进行化学教学。 凭借这一职业奖，合成有机项目正在支持西北大学化学系 Frank E. McDonald 博士的研究和教育计划。 McDonald教授的研究重点是开发合成聚醚天然产物和具有重要生物特性的化合物的新方法。 处理器麦克唐纳教育计划的重点是通过鼓励使用归纳推理技能来进行化学教学。