SBIR Phase II: Advanced Micro-Pixelized Scintillator for Structural Biology

SBIR 第二阶段：用于结构生物学的先进微像素化闪烁体

• 批准号: 9983337
• 负责人: Vivek Nagarkar
• 金额: $ 40万
• 依托单位: Radiation Monitoring Devices Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-01 至 2003-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9983337&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Advanced; Micro

This Small Business Innovation Research Phase II project is aimed at developing a novel digital x-ray detector for macromolecular crystallography. This detector is based on a new generation micro-pixelized scintillator optically coupled to a large area digital readout array. The micro-pixelized scintillator will provide a unique combination of very high sensitivity, spatial resolution, and signal to noise ratios resulting in excellent point spread function (PSF), thus improving the quality of the measured Bragg peak data.When integrated with a large area digital optical detector it will allow a wide dynamic range and substantially enhanced throughput at relatively low costs. In addition to the structural biology application, the proposed detector would find widespread use in instrumentation wherever high-resolution x-ray imaging is used.

这个小型企业创新研究二期项目旨在开发一种用于大分子晶体学的新型数字x射线探测器。该探测器基于新一代微像素闪烁体与大面积数字读出阵列光学耦合。微像素化闪烁体将提供非常高的灵敏度、空间分辨率和信噪比的独特组合，从而产生优异的点扩展函数（PSF），从而提高测量布拉格峰数据的质量。当与大面积数字光学探测器集成时，它将以相对较低的成本实现宽动态范围和显着提高的吞吐量。除了结构生物学应用之外，所提出的探测器将广泛用于任何使用高分辨率x射线成像的仪器。