CAREER: Hydrophobic Self-Assembly in Water and Integrated Educational Initiatives

该项目涉及一个以水中自组装领域研究为中心的综合职业发展计划。该研究探索了自组装和分子识别的各个方面，特别是那些模仿自然界中疏水效应被发现影响功能分子组装的许多实例的研究。具体目标包括合成自互补的表面两亲分子，作为在水中自组装的构建块。识别基元将包括作为铵基和含赖氨酸肽受体的面部两亲体，涉及万古霉素耐药细菌的出现。有了这个职业奖，有机和大分子化学项目的有机动力学项目支持马里兰大学帕克分校的Lyle D. Isaacs教授的研究和教育活动。艾萨克斯教授试图了解自然界中的分子是如何相互识别并聚集在一起形成特定的功能聚集体的。这将通过探索水中分子的相互作用来实现，依靠放置在预先确定位置的这些分子的防水表面。化学知识在线资源的激增和计算化学软件包的发展已经改变了化学家学习和研究的方式。教育计划将在这些领域开发课程模块，并通过开发用于课堂的超分子化学成分与研究目标相结合。

This project involves an integrated career development plan centered around research in the area of self-assembly in water. The research explores various aspects of self-assembly and molecular recognition, particularly those which mimic the many instances in nature where hydrophobic effects are found to effect functional molecular assemblies. Specific aims include the synthesis of self-complimentary facially amphiphilic molecules as building blocks for self-assembly in water. Recognition motifs will include facial amphiphiles as receptors for ammonium groups and lysine containing peptides, implicated in the emergence of vancomycin resistant bacteria.With this CAREER Award, the Organic and Macromolecular Chemistry Program's Organic Dynamics Program supports the research and educational activities of Professor Lyle D. Isaacs of the University of Maryland College Park. Professor Isaacs seeks to understand how molecules in nature recognize each other and come together to form specific, functional aggregates. This will be carried out by exploring the interactions of molecules in water, relying on water-repellent surfaces on these molecules placed in pre-determined locations. The proliferation of on-line resources for chemical knowledge and the development of computational chemistry packages has changed the way in which chemists learn and do research. The educational plans will develop course modules in these areas, and integrate with the research goals through the development of supramolecular chemistry components for use in the classroom.