CAREER: Hydrophobic Self-Assembly in Water and Integrated Educational Initiatives

该项目涉及一个综合的职业发展计划，围绕在水中自组装领域的研究。 该研究探索了自组装和分子识别的各个方面，特别是那些模仿自然界中发现疏水效应影响功能分子组装的许多实例的方面。 具体目标包括合成自互补的表面两亲性分子作为在水中自组装的结构单元。 识别基序将包括表面两亲物作为铵基团的受体和含赖氨酸的肽，与万古霉素耐药菌的出现有关。马里兰州大学帕克分校的艾萨克斯说。 Isaacs教授试图了解自然界中的分子如何相互识别并聚集在一起形成特定的功能性聚集体。 这将通过探索分子在水中的相互作用来进行，依赖于放置在预定位置的这些分子上的防水表面。 化学知识在线资源的激增和计算化学软件包的发展改变了化学家学习和研究的方式。 教育计划将开发这些领域的课程模块，并通过开发超分子化学组件与研究目标相结合，供课堂使用。

This project involves an integrated career development plan centered around research in the area of self-assembly in water. The research explores various aspects of self-assembly and molecular recognition, particularly those which mimic the many instances in nature where hydrophobic effects are found to effect functional molecular assemblies. Specific aims include the synthesis of self-complimentary facially amphiphilic molecules as building blocks for self-assembly in water. Recognition motifs will include facial amphiphiles as receptors for ammonium groups and lysine containing peptides, implicated in the emergence of vancomycin resistant bacteria.With this CAREER Award, the Organic and Macromolecular Chemistry Program's Organic Dynamics Program supports the research and educational activities of Professor Lyle D. Isaacs of the University of Maryland College Park. Professor Isaacs seeks to understand how molecules in nature recognize each other and come together to form specific, functional aggregates. This will be carried out by exploring the interactions of molecules in water, relying on water-repellent surfaces on these molecules placed in pre-determined locations. The proliferation of on-line resources for chemical knowledge and the development of computational chemistry packages has changed the way in which chemists learn and do research. The educational plans will develop course modules in these areas, and integrate with the research goals through the development of supramolecular chemistry components for use in the classroom.