Templated Synthesis and Applications of Cucurbituril Type Receptors

大分子，超分子和纳米化学（MSN）计划支持教授莱尔·艾萨克斯在马里兰州大学公园，重点是葫芦[n]脲（CB[n]）家族的分子容器化合物的合成和超分子化学的发展工作。 虽然非官能化的CB[n]化合物被超分子化学界广泛探索，但具有反应性官能团的CB[n]衍生物的制备仍然是一个重大挑战。 Isaacs小组正在开发稳健的合成方法，用于定制合成单官能化CB[n]衍生物。 这些衍生物将被探索用于各种目的，包括它们的固定到固相色谱，用于制备刺激响应分子机器，并促进生物分子在水中的二聚化用于诊断和传感应用。 Isaacs小组还开发了一系列可免费下载的视频，用于万维网发布，这些视频基于本科有机化学中具有挑战性的问题，说明了实践化学家如何解决问题。容器在日常生活中非常重要，包括保存食品和将物品运送到特定位置。 分子容器对分子做同样的事情，并构成家用产品和药物配方的重要成分。 Isaacs小组开发的化合物和程序将通过提供一系列带有反应性官能团的容器化合物来影响学术和工业科学，这些反应性官能团允许它们并入先进的功能系统。 该计划鼓励本科生和来自代表性不足的群体的学生参与化学研究。 免费提供的网络视频显示了化学家解决本科有机化学中具有挑战性的问题，有望提高全球本科社区的学习成果。

The Macromolecular, Supramolecular and Nanochemistry (MSN) Program supports the work of Professor Lyle Isaacs at the University of Maryland College Park which focuses on the development of the synthetic and supramolecular chemistry of the cucurbit[n]uril (CB[n]) family of molecular container compounds. Although unfunctionalized CB[n] compounds are being widely explored by the supramolecular chemistry community, the preparation of CB[n] derivatives displaying reactive functional groups is still a major challenge. The Isaacs group is developing robust synthetic methods for the tailor-made synthesis of monofunctionalized CB[n] derivatives. These derivatives will be explored for a variety of purposes including their immobilization to solid phases for chromatography, for the preparation of stimuli responsive molecular machines, and to promote the dimerization of biomolecules in water for diagnostic and sensing application. The Isaacs group is also developing a series of freely downloadable videos for world wide web distribution based on challenging problems in Undergraduate Organic Chemistry that illustrate how a practicing chemist solves problems.Containers are tremendously important in everyday life including the preservation of foodstuffs and the shipping of items to specific locations. Molecular containers do the same things for molecules and constitute vital ingredients in household products and pharmaceutical formulations. The compounds and procedures developed by the Isaacs group will impact both academic and industrial science by providing a series of container compounds bearing reactive functional groups that allow their incorporation into advanced functional systems. This program encourages the participation of undergraduates and students from under-represented groups in chemical research. Freely available web videos showing a chemist solving challenging problems in undergraduate organic chemistry promises to enhance the learning outcome of the global undergraduate community.