CAREER: Research and Educational Initiatives Focusing on Polymers in Bioengineering: Nanoscale Patterning of Surfaces

该项目的目标是开发新的实验技术，以在聚合物表面上产生可控制的纳米级生物分子模式。该项目的具体目标是：(1)使用原子力显微镜（AMF）在聚合物薄膜上制造纳米尺度的图案，(2)使用聚合物-AMF尖端相互作用的分子动力学模拟来预测所需图案形成的条件，以及(3)通过在纳米尺度图案表面上固定生物分子来制造生物传感器的可行性。

The objective of this project is to develop new experimental techniques to produce controlled nanoscale patterns of biomolecules on polymer surfaces. The specific goals of this project are to: (1) fabricate nanoscale patterns on polymer films using atomic force microscopy (AMF), (2) use molecular dynamics simulations of polymer-AMF tip interactions to predict conditions for desired pattern formation, and (3) demonstrate the feasibility of fabricating a biosensor by immobilizing biomolecules on the nanoscale patterned surfaces.