CAREER: Structure-Function Studies of a Neurotrophin Receptor Isoform with Novel Neural Differentiation Function
职业:具有新型神经分化功能的神经营养蛋白受体亚型的结构功能研究
基本信息
- 批准号:9984562
- 负责人:
- 金额:$ 49.9万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2000
- 资助国家:美国
- 起止时间:2000-04-15 至 2005-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Copie9984562This research program focuses on solving the three-dimensional structure of the intracellular domain of a naturally occurring neurotrophin receptor isoform, ICD-TK- trkC, which was recently shown, together with P75 receptor activation, to be effective at promoting neuronal differentiation. Modern multi-dimensional (1H, 15N, 13C) NMR methods will be used to determine its 3D structure in solution at high resolution. The goal of this work is to provide structural and molecular data that, together with site-directed mutagenesis experiments and biochemical assays, will bring insight as to the mechanism(s) by which TK- trkC promotes differentiation of neural cells.The objective of this research is to provide fundamental knowledge about key biochemical interactions regulating neuronal development. This research will integrate the PI's major educational initiatives, including the recruitment of Native American students into the sciences, establishment of "hands on" experiences and "mini-rotations" in research laboratories for undergraduate students, and the organization of seminar series and mentorship programs to encourage under-represented student groups to pursue majors and/or research project in science. This project is an integral component of the PI's involvement with the cross-disciplinary research and educational initiatives being developed at Montana State University through an NSF-sponsored (IGERT) graduate training program.
Copie9984562该研究项目的重点是解决天然存在的神经营养蛋白受体亚型 ICD-TK-trkC 细胞内结构域的三维结构,最近显示它与 P75 受体激活一起可有效促进神经元分化。 现代多维(1H、15N、13C)NMR 方法将用于以高分辨率确定其溶液中的 3D 结构。这项工作的目标是提供结构和分子数据,结合定点诱变实验和生化测定,将深入了解 TK-trkC 促进神经细胞分化的机制。这项研究的目的是提供有关调节神经元发育的关键生化相互作用的基础知识。这项研究将整合PI的主要教育举措,包括招募美国原住民学生进入科学领域、为本科生在研究实验室中建立“实践”经验和“迷你轮换”,以及组织研讨会系列和导师计划,以鼓励代表性不足的学生群体追求科学专业和/或研究项目。该项目是 PI 参与蒙大拿州立大学通过 NSF 资助的 (IGERT) 研究生培训计划开发的跨学科研究和教育计划的一个组成部分。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Valerie Copie其他文献
Dynamical Studies Of A Temperature-Sensitive Mutant Of The Tryptophan Repressor Protein, L75F-TrpR
- DOI:
10.1016/j.bpj.2008.12.1618 - 发表时间:
2009-02-01 - 期刊:
- 影响因子:
- 作者:
Valerie Copie;Brian Tripet;Anupam Goel;Lucas Nerbert;Jannette Carey - 通讯作者:
Jannette Carey
Valerie Copie的其他文献
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{{ truncateString('Valerie Copie', 18)}}的其他基金
MRI: Track 3: Acquisition of a Helium Recovery System to Reduce the Consumption of Helium of Montana State University's NMR Core Facility
MRI:轨道 3:采购氦气回收系统以减少蒙大拿州立大学 NMR 核心设施的氦气消耗
- 批准号:
2320009 - 财政年份:2023
- 资助金额:
$ 49.9万 - 项目类别:
Standard Grant
Microbial Dark Matter: Forging New Discoveries in Metabolism
微生物暗物质:新陈代谢的新发现
- 批准号:
1714556 - 财政年份:2017
- 资助金额:
$ 49.9万 - 项目类别:
Standard Grant
MRI: Acquisition of a cryoprobe- and autosampler-equipped AVANCE III 500 MHz solution NMR
MRI:采集配备冷冻探头和自动进样器的 AVANCE III 500 MHz 解决方案 NMR
- 批准号:
1532078 - 财政年份:2015
- 资助金额:
$ 49.9万 - 项目类别:
Standard Grant
Dynamical Studies of Functionally Altered Mutants of the Tryptophan Repressor Protein
色氨酸阻遏蛋白功能改变突变体的动力学研究
- 批准号:
0444056 - 财政年份:2005
- 资助金额:
$ 49.9万 - 项目类别:
Continuing Grant
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