CAREER: Nitrogen/Sulfur Clusters of Iron: Synthetic Approaches to Nitrogenase Chemistry

职业:铁的氮/硫簇:固氮酶化学的合成方法

基本信息

  • 批准号:
    9984645
  • 负责人:
  • 金额:
    $ 40万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Continuing Grant
  • 财政年份:
    2000
  • 资助国家:
    美国
  • 起止时间:
    2000-02-15 至 2005-01-31
  • 项目状态:
    已结题

项目摘要

This CAREER award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports research on the mechanism of action of the iron-sulfur cofactor in nitrogenase enzymes, by Professor Sonny Lee of the Department of Chemistry at Princeton University. This cofactor is believed to carry out the reduction of dinitrogen to ammonia, but its mode of action is unknown. Two complementary approaches will be employed to obtain information on the mechanism: (1) the reaction chemistry of imidoiron(II) cubane cluster compounds, in particular nitrogen-nitrogen bond cleavage in cluster formation and disproportionation reactions catalyzed by the clusters, will be investigated and; (2) new iron-nitrogen-sulfur complexes will be synthesized and their reactivities characterized. Clusters containing a new class of sterically-hindered, chelating thiolate/thioether ligands will also be synthesized and their activation of nitrogen-nitrogen double and triple bonds examined.The goal of this research is to determine how a metal (iron) cluster in the nitrogenase enzymes functions. These enzymes provide fixed atmospheric nitrogen to living organisms, but the chemistry of this process remains a mystery. The results of this study will help to determine the mechanism of this critical enzymatic process. In addition, the knowledge gained can be used in the design of artificial systems to convert nitrogen from the air into ammonia and other useful compounds under much milder conditions than in current industrial processes. A new course combining research topics and cooperative learning will be developed, as well as an outreach program to the area public schools staffed by Princeton student-teachers and local industrial scientists. These activities will assist in the multidisciplinary training of both graduate and undergraduate students, and improve science education and public awareness of science in the primary and secondary schools.
无机,生物无机和有机化学计划的职业奖支持了普林斯顿大学化学系的Sonny Lee教授对固氮酶中铁硫辅因子作用机制的研究。这种辅因子被认为可以将二氮还原为氨,但其作用方式尚不清楚。将采用两种互补的方法来获得关于该机制的信息:(1)将研究亚氨基铁(II)立方烷簇合物的反应化学,特别是簇合物形成中的氮-氮键断裂和簇合物催化的缩合反应;(2)将合成新的铁-氮-硫络合物并表征其反应活性。簇含有一类新的空间位阻,螯合硫醇盐/硫醚配体也将被合成和其激活的氮-氮双键和三键examined.The本研究的目标是确定如何在固氮酶的金属(铁)簇的功能。这些酶为生物体提供固定的大气氮,但这一过程的化学过程仍然是一个谜。本研究的结果将有助于确定这一关键酶促过程的机制。此外,所获得的知识可用于人工系统的设计,以在比当前工业过程温和得多的条件下将空气中的氮转化为氨和其他有用的化合物。将开发一门结合研究课题和合作学习的新课程,以及一个由普林斯顿学生教师和当地工业科学家组成的地区公立学校的推广计划。这些活动将有助于对研究生和本科生进行多学科培训,并改善中小学的科学教育和公众对科学的认识。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Sonny Lee其他文献

Calibration Bias and the Interpretation of Clinical Learning Environment Perceptions Surveys.
校准偏差和临床学习环境感知调查的解释。
  • DOI:
  • 发表时间:
    2020
  • 期刊:
  • 影响因子:
    0
  • 作者:
    D. Deemer;John M. Byrne;L. Loo;David Puder;Karina D. Torralba;Sonny Lee;T. Kashner
  • 通讯作者:
    T. Kashner
17 PERIPARTUM ANTIBIOTIC EXPOSURE INDUCES PERSISTENT GUT DYSBIOSIS, IMPAIRS THE DEVELOPMENT OF IMMUNE TOLERANCE, AND INCREASES RISK FOR INFLAMMATORY BOWEL DISEASE IN GENETICALLY SUSCEPTIBLE OFFSPRING
  • DOI:
    10.1053/j.gastro.2019.01.235
  • 发表时间:
    2019-02-01
  • 期刊:
  • 影响因子:
  • 作者:
    Jun Miyoshi;Vanessa Leone;Sawako Miyoshi;Sonny Lee;Aki Sakatani;A. Murat Eren;Eugene Chang
  • 通讯作者:
    Eugene Chang

Sonny Lee的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Sonny Lee', 18)}}的其他基金

CAREER: How do rhizosphere associated microorganisms and plant host interact to regulate soil microbial processes?
职业:根际相关微生物和植物宿主如何相互作用来调节土壤微生物过程?
  • 批准号:
    2238633
  • 财政年份:
    2023
  • 资助金额:
    $ 40万
  • 项目类别:
    Continuing Grant
Cluster Transformations Relevant to Nitrogenase Cofactor
与固氮酶辅因子相关的簇转化
  • 批准号:
    9632416
  • 财政年份:
    1996
  • 资助金额:
    $ 40万
  • 项目类别:
    Standard Grant
Postdoctoral Research Fellowships in Chemistry
化学博士后研究奖学金
  • 批准号:
    9203549
  • 财政年份:
    1992
  • 资助金额:
    $ 40万
  • 项目类别:
    Fellowship Award

相似海外基金

Signaling functions of reactive oxygen, nitrogen, and sulfur species in the root abscission mechanism of the water-floating fern Azolla pinnata
活性氧、氮和硫物种在水浮蕨满江红根系脱落机制中的信号功能
  • 批准号:
    23K05493
  • 财政年份:
    2023
  • 资助金额:
    $ 40万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Collaborative Research: Multi-phase Sulfur and Nitrogen Chemistry in Air and Snow during Alaskan Layered Pollution and Chemical Analysis (ALPACA)
合作研究:阿拉斯加层状污染和化学分析(羊驼)期间空气和雪中的多相硫和氮化学
  • 批准号:
    2109011
  • 财政年份:
    2021
  • 资助金额:
    $ 40万
  • 项目类别:
    Standard Grant
Collaborative Research: Multi-phase Sulfur and Nitrogen Chemistry in Air and Snow during Alaskan Layered Pollution and Chemical Analysis (ALPACA)
合作研究:阿拉斯加层状污染和化学分析(羊驼)期间空气和雪中的多相硫和氮化学
  • 批准号:
    2109023
  • 财政年份:
    2021
  • 资助金额:
    $ 40万
  • 项目类别:
    Standard Grant
Collaborative Research: Multi-phase Sulfur and Nitrogen Chemistry in Air and Snow during Alaskan Layered Pollution and Chemical Analysis (ALPACA)
合作研究:阿拉斯加层状污染和化学分析(羊驼)期间空气和雪中的多相硫和氮化学
  • 批准号:
    2109134
  • 财政年份:
    2021
  • 资助金额:
    $ 40万
  • 项目类别:
    Standard Grant
Molecular Recognition of Anionic Sulfur, Oxygen, and Nitrogen Species
阴离子硫、氧和氮物种的分子识别
  • 批准号:
    2107602
  • 财政年份:
    2021
  • 资助金额:
    $ 40万
  • 项目类别:
    Standard Grant
Collaborative Research: Multi-phase Sulfur and Nitrogen Chemistry in Air and Snow during Alaskan Layered Pollution and Chemical Analysis (ALPACA)
合作研究:阿拉斯加层状污染和化学分析(羊驼)期间空气和雪中的多相硫和氮化学
  • 批准号:
    2109098
  • 财政年份:
    2021
  • 资助金额:
    $ 40万
  • 项目类别:
    Standard Grant
Synthesis and Characterization of Nitrogen and Sulfur Donor-Acceptor Stenhouse Adducts
氮和硫供体-受体 Stenhouse 加合物的合成与表征
  • 批准号:
    10724739
  • 财政年份:
    2021
  • 资助金额:
    $ 40万
  • 项目类别:
Collaborative Research: Multi-phase Sulfur and Nitrogen Chemistry in Air and Snow during Alaskan Layered Pollution and Chemical Analysis (ALPACA)
合作研究:阿拉斯加层状污染和化学分析(羊驼)期间空气和雪中的多相硫和氮化学
  • 批准号:
    2109240
  • 财政年份:
    2021
  • 资助金额:
    $ 40万
  • 项目类别:
    Standard Grant
Innovative Sulfur-Nitrogen Ligands for Promising Ln3+ Single Molecule Magnets
用于有前景的 Ln3 单分子磁体的创新硫氮配体
  • 批准号:
    419278547
  • 财政年份:
    2019
  • 资助金额:
    $ 40万
  • 项目类别:
    Research Grants
Deciphering the novel link between sulfur assimilation and nitrogen fixation in methanogenic archaea
破译产甲烷古菌中硫同化和固氮之间的新联系
  • 批准号:
    1817819
  • 财政年份:
    2018
  • 资助金额:
    $ 40万
  • 项目类别:
    Standard Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了