Molecular Recognition of Anionic Sulfur, Oxygen, and Nitrogen Species

阴离子硫、氧和氮物种的分子识别

• 批准号: 2107602
• 负责人: Michael Pluth
• 金额: $ 38万
• 依托单位: University of Oregon Eugene
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2107602&HistoricalAwards=false
• 关键词: Molecular; Recognition; Anionic; Sulfur; Oxygen

With the support of the Macromolecular, Supramolecular and Nanochemistry Program in the NSF Division of Chemistry, Professor Michael Pluth of the University of Oregon will develop general methods to bind, differentiate, and recognize under-investigated anionic sulfur-, oxygen-, and nitrogen-containing species. These small molecules play diverse and important roles in biological systems and the environment. This research aims to gain a better fundamental understanding of how these species behave in different systems. Through conducting this interdisciplinary research, graduate and undergraduate students will receive training in organic synthesis and analytical studies in supramolecular chemistry. In addition, the research team will engage students in local underserved middle schools in hands-on science activities to expand their exposure to STEM (science, technology, engineering and mathematics).Professor Michael Pluth and his research team will investigate the molecular recognition of anionic reactive sulfur, oxygen and nitrogen species, such as peroxynitrite, nitrite, thionitrite, and perthionitrite. This project will focus on three specific aims. In Aim 1, synthetic anion-binding hosts will be used to elucidate the factors that influence binding of anionic guests including NO3- (nitrate), NO2- (nitrite), SNO- (thionitrite) and SSNO- (perthionitrite). In Aim 2, additional host receptors will be rationally designed and synthesized for specific recognition of SNO- and SSNO-. In Aim 3, the research team will investigate whether the anion-binding receptors can be used to modify the chemical speciation and reactivity of reactive small molecules. Information gleaned from these investigations is expected to expand the understanding of what specific recognition motifs can be used to stabilize small molecule regulators and control the equilibria of their interconversion.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在NSF化学部大分子、超分子和纳米化学项目的支持下，俄勒冈州大学的Michael Pluth教授将开发通用方法来结合、区分和识别研究不足的阴离子含硫、氧和氮物质。这些小分子在生物系统和环境中发挥着各种重要作用。这项研究旨在更好地了解这些物种在不同系统中的行为。通过进行这项跨学科的研究，研究生和本科生将接受有机合成和超分子化学分析研究的培训。 此外，该研究团队还将邀请当地服务水平较低的中学的学生参与科学实践活动，以扩大他们对STEM（科学、技术、工程和数学）的接触。Michael Pluth教授及其研究团队将研究阴离子活性硫、氧和氮物种的分子识别，如过氧亚硝酸盐、亚硝酸盐、亚硫硝酸盐和过亚硫硝酸盐。该项目将侧重于三个具体目标。目的1：利用人工合成的阴离子结合主体来阐明影响阴离子客体结合的因素，包括NO3-（硝酸根）、NO2-（亚硝酸根）、SNO-（亚硫硝酸根）和SSNO-（过亚硫硝酸根）。在目标2中，将合理设计和合成额外的宿主受体以特异性识别SNO-和SSNO-。在目标3中，研究小组将研究阴离子结合受体是否可用于改变反应性小分子的化学形态和反应性。从这些调查中收集的信息预计将扩大哪些特定的识别基序可以用来稳定小分子调节剂和控制其相互转换的平衡的理解。这个奖项反映了NSF的法定使命，并已被认为是值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估的支持。