CAREER: Metathesis Strategies to Diverse Sulfur- and Phosphorus-Based Oligomers

本研究的重点是开发开环复分解聚合（ROMP）策略，以获得结构多样的含有硫基和磷基官能团的聚合物基序。重点将放在设计和合成不对称单体单位含有降冰片烯骨架。采用ROMP方法制备基于磺胺的寡肽、含有c2对称口袋的磺胺支架、聚合核酸支架和聚合脂质支架。这些不同的聚合物可作为新型药物制剂、不对称催化配体、人工脂质支架和DNA/RNA反义剂。该项目的教育部分着重于研究生对本科生的指导，一个充满活力的本科生辅导计划，多媒体实验前准备和讲座演示，以及高中推广。通过这个职业奖，有机和大分子化学项目支持堪萨斯大学化学系Paul R. Hanson博士的研究和教育活动。汉森教授将重点研究与制药相关的硫基和磷基低聚物的开发。教育活动的重点是指导、辅导和本科课程开发。

The focus of this research is the development of ring-opening metathesis polymerization (ROMP) strategies to structurally diverse polymeric motifs that contain sulfur- and phosphorus-based functional groups. Emphasis will be placed on the design and synthesis of asymmetric monomeric units containing norbornene skeletons. Sulfonamide-based oligopeptides, sulfamide scaffolds containing C2-symmetric pockets, polymeric nucleic acid scaffolds and polymeric lipid scaffolds will be prepared using the ROMP methodology. These diverse polymers can potentially serve as novel pharmaceutical agents, ligands in asymmetric catalysis, artificial lipid scaffolds and DNA/RNA antisense agents. The educational portion of the project stresses graduate student mentoring of undergraduates, a vigorous undergraduate tutoring program, multi-media pre-laboratory preparation and lecture presentation, and high school outreach.With this CAREER award, the Organic and Macromolecular Chemistry Program is supporting the research and educational activities of Dr. Paul R. Hanson of the Department of Chemistry at the University of Kansas. Professor Hanson will focus his research on the development of pharmaceutically relevant sulfur- and phosphorus-based oligomers. The foci of the educational activities involve mentoring, tutoring and undergraduate course development.