New Methods in Phosphorus Chemistry

该项目解决了使用磷酸三酯作为临时系链来生成单环和双环磷酸盐的问题，随后进行选择性裂解反应，利用磷酸系链提供的潜在离去基能力。这些研究利用了磷的几个固有特征，包括赋予手性和易偶联途径的多价性，提供多价活化的潜力，以及赋予p系链中保护基团特征的正交稳定性/反应性谱。综上所述，磷酸盐系链具有临时系链、保护基团和潜在离去基团的多重作用。这种磷酸三酯方法将应用于制备差异保护多元醇的过程中，以实现生物相关靶标的全合成，包括dolabelides、leustroducsin和fostriecin。有了这个奖项，有机和大分子化学项目支持了堪萨斯大学化学系保罗·r·汉森博士的研究。汉森教授和他的学生们正在开发新的有机合成方法，利用磷原子独特的结构和化学特性。磷原子在指导和控制随后的化学反应中起着多功能作用，为合成具有有趣生物活性的复杂有机分子提供了新的策略。Hanson教授还担任少数民族学生指导计划的主任，该计划旨在为有兴趣从事化学和医学科学职业的少数民族本科生和研究生提供导师。

The project addresses the use of phosphate triesters as temporary tethers to generate mono- and bicyclic phosphates, followed by selective cleavage reactions that exploit the latent leaving group ability provided by the phosphate tether. These studies exploit several features inherent to phosphorus, including multi-valency that bestows both chirality and facile coupling pathways, the potential to provide multivalent activation, and an orthogonal stability/reactivity profile that imparts protecting group features in the P-tether. Thus, overall, the phosphate tether serves a multi-faceted role as temporary tether, protecting group, and latent leaving group. This phosphate triester methodology will be applied to the preparation of differentially protected polyols en route to the total synthesis of biologically relevant targets, including the dolabelides, leustroducsin, and fostriecin.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Paul R. Hanson of the Department of Chemistry at the University of Kansas. Professor Hanson and his students are developing novel methods for organic synthesis that exploit the unique structural and chemical features of the phosphorus atom. The phosphorus atom plays a multifunctional role in directing and controlling ensuing chemical reactions, affording novel strategies for the synthesis of complex organic molecules displaying interesting biological activity. Professor Hanson also serves as the Director of a Minority Student-Mentoring Program, designed to provide mentors for minority undergraduate and graduate students interested in pursuing careers in the chemical and medical sciences.