Career: Quantitative Studies of Weak Interactions in Aqueous Solution: Anion Binding by Cationic Cyclodextrins

职业：水溶液中弱相互作用的定量研究：阳离子环糊精与阴离子的结合

• 批准号: 9985300
• 负责人: Paul Smith
• 金额: $ 38万
• 依托单位: University of Maryland Baltimore County
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-02-15 至 2004-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9985300&HistoricalAwards=false
• 关键词: Career; Quantitative; Studies; Weak; Interactions

This project has as its goal the integration of research and educational activities. The research activities involve the determination of thermodynamic binding parameters for a number of biologically important ion-pairing interactions involving ammonium and guanidinium groups. These determinations will be made in aqueous solution using a series of cationic cyclodextrin derivatives and appropriate anionic guests. Methods employed for these studies will include titration calorimetry, NMR spectroscopy and molecular modeling.With this Award, the Organic and Macromolecular Chemistry Program supports the research and educational activities of Professor Paul J. Smith of the University of Maryland Baltimore County. Professor Smith will integrate research and education by involving students in the study of chemical problems that are at the interface between chemistry and biology. The research exploring the binding of biologically important ions will indeed have important ramifications in biochemistry and in molecular design.

这个项目的目标是将研究和教育活动结合起来。研究活动包括确定一些涉及铵和胍基团的重要生物离子对相互作用的热力学结合参数。这些测定将在水溶液中使用一系列阳离子环糊精衍生物和适当的阴离子客体进行。这些研究采用的方法包括滴定量热法、核磁共振波谱法和分子模型。通过这个奖项，有机和大分子化学项目支持马里兰大学巴尔的摩县分校Paul J. Smith教授的研究和教育活动。史密斯教授将把研究和教学结合起来，让学生参与到化学和生物学交界的化学问题的研究中来。探索生物重要离子结合的研究将在生物化学和分子设计中产生重要的影响。