Structural Investigation of Molecularly Engineering Polymers Prepared by Enzymatic Polymerization

酶聚合制备分子工程聚合物的结构研究

• 批准号: 9986644
• 负责人: Ashok Cholli
• 金额: $ 29.4万
• 依托单位: University of Massachusetts Lowell
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-02-01 至 2004-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9986644&HistoricalAwards=false
• 关键词: Structural; Investigation; Molecularly; Engineering; Polymers

The key objective of the proposed research is to understand the basic mechanisms of the oxidative enzymatic polymerization of electroactive polymers using multi-nuclei solution and solid state NMR spectroscopy. This approach involves a simple, one-pot, environmentally compatible reaction that leads to the synthesis of a new class of water soluble, electrically and photonically active polymers. This nobel biocatalytic approach provides, obviates the experimental difficulties previously encountered with traditional chemical reactions and now affords exciting new opportunities to understand these fundamental oxidative mechanisms. NMR spectroscopy will be used extensively in this program both as a probe to understand these oxidative coupling mechanisms and as a tool to optimize the reactions such that the electrical and optical properties of the resulting polymers may be enhanced. The main focus of this effort will involve two sub areas of investigation using both multi-nuclei solution and solid-state NMR techniques: (a) Oxidative coupling mechanisms for phenols and substituted phenols, and (b) Reaction mechanisms of enzymatic polymerization for polyaniline and the role of polyanionic or polycationic templates on enzymatic polymerization. This study will significantly advance the basic understanding of the mechanisms and nature of enzymatic oxidative coupling and as a result allow for the controlled optimization of the reactions. It is expected that this new insight will led to the ability to molecularly engineer a wide variety of novel electroactive polymers that should find wide commercial application.This biocatalytic approach to polymer synthesis is environmentally friendly and offers an effective alternative approach to the synthesis of electroactive polymers. The processing of these enzymatically-synthesized polymers can also be carried out in an environmentally benign manner given their water solubility. Advancement of research in this area thus will help to reduce the use of hazardous chemicals both during the synthetic steps and processing. A deeper understanding of the molecular basis of the enzymatic synthesis may lead to potential technological innovations beneficial to the society.

拟议研究的主要目标是了解使用多核溶液和固态NMR光谱法对电活性聚合物氧化酶聚合的基本机制。 这种方法涉及一种简单的，一锅，环境兼容的反应，导致合成新的水溶性，电和光子活性聚合物。 这种诺贝尔生物催化方法提供了避免以前传统化学反应遇到的实验困难，现在为了解这些基本氧化机制提供了令人兴奋的新机会。 NMR光谱法将在该程序中广泛使用，既是理解这些氧化耦合机制的探针，又是优化反应的工具，以便可以增强所得聚合物的电气和光学特性。 这项工作的主要重点将涉及使用多核溶液和固态NMR技术的两个子研究领域：（a）酚和取代酚的氧化偶联机制，以及（b）酶聚合物的酶聚合物的反应机制，用于聚苯胺和多苯基离子化或聚乙酸或多脑化的作用。 这项研究将显着提高人们对酶促氧化偶联的机制和性质的基本理解，从而使反应受控优化。 可以预期，这种新的见解将导致能够分子设计出各种新型的电活性聚合物，它们应该找到广泛的商业应用。这种聚合物合成的生物催化方法对环境友好，并为综合电动聚合物的合成提供了有效的替代方法。 鉴于它们的水溶性，这些酶合成的聚合物的加工也可以以环境方式进行。 因此，该领域的研究进步将有助于减少合成步骤和处理过程中危险化学物质的使用。 对酶促合成的分子基础的更深入了解可能会导致潜在的技术创新对社会有益。