Physiological significance of transient receptor potential (TRPC3) ion channels in the cochlea

耳蜗瞬时受体电位（TRPC3）离子通道的生理意义

• 批准号: DP1097202
• 负责人: Prof Gary Housley
• 金额: $ 19.49万
• 依托单位: The University of New South Wales
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1097202
• 关键词: Physiological; significance; transient; receptor; potential

The project seeks to discover the function of transient receptor potential (TRPC3) ion channels in the cochlea. Recent studies have suggested that these proteins, which are expressed by the sensory and neural cells, are key elements regulating sound transduction and neurotransmission. The new knowledge about the physiological processes underlying hearing that this work will provide, will significantly benefit national and international translational research that seeks to develop systems for controlling the sensitivity of our senses, developing biosensors, interacting with neural networks and developing neural prostheses. International collaborators in this project have enabled development of new models, technology and research training opportunities.

该项目旨在发现瞬时受体电位（TRPC 3）离子通道在耳蜗中的功能。 最近的研究表明，这些由感觉和神经细胞表达的蛋白质是调节声音传导和神经传递的关键元件。这项工作将提供有关听觉基础生理过程的新知识，将大大有利于国家和国际转化研究，这些研究旨在开发控制我们感官灵敏度的系统，开发生物传感器，与神经网络互动和开发神经假体。该项目的国际合作者开发了新的模型，技术和研究培训机会。