Peptide Based Macrocycles as Chemosensors for Metal Ions

该项目的长期目标是开发结合金属离子和信号特异性金属离子结合的化学传感分子。 本研究的具体目的是设计和合成肽衍生的大环配体，其具有指示金属离子结合的内在荧光信号。 该策略是采用基于肽的大环化合物，其掺入显示荧光响应的内在信号分子。 用核磁共振、圆二色谱、电位法和荧光法对离子结合选择性进行了比较研究。 这些大环的基态性质，在固态以及在溶液中，将通过X射线衍射方法，核磁共振和构象分析进行研究。有了这个奖项，有机和大分子化学程序的有机动力学程序支持南方大学的Maria Ngu-Schwemlein教授的研究。 Ngu-Schwemlein教授提议研究金属离子与以蛋白质为模型的小分子之间的相互作用。 随着这些分子和特定离子之间的可检测的相互作用，应用于离子选择性传感器，离子色谱法和金属离子解毒将是可能的。

This project has as its long-term goal the development of chemosensing molecules that bind metal ions and signal specific metal ion binding. The specific aims of this study are to design and synthesize peptide derived macrocyclic ligands with an intrinsic fluorescent signal to indicate metal ion binding. The strategy is to employ peptide based macrocycles incorporating intrinsic signalling molecules that display a fluorescence response. The ion binding selectivities will be comparatively studied by NMR, CD, potentiometry and fluorescence techniques. Ground state properties of these macrocycles, in the solid state as well as in solution, will be investigated by X-ray diffraction methods, NMR and conformational analysis.With this Award, the Organic and Macromolecular Chemistry Program's Organic Dynamics Program supports the research of Professor Maria Ngu-Schwemlein of Southern University. Professor Ngu-Schwemlein proposes to study the interactions between metal ions and small molecules that are modeled on proteins. With a detectable interaction between these molecules and specific ions, applications toward ion selective sensors, ion chromatography, and metal ion detoxification will be possible.