Peptide Based Macrocycles as Chemosensors for Metal Ions

基于肽的大环化合物作为金属离子的化学传感器

• 批准号: 0071632
• 负责人: Maria Ngu-Schwemlein
• 金额: $ 16.11万
• 依托单位: Southern University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0071632&HistoricalAwards=false
• 关键词: Peptide; Based; Macrocycles; Chemosensors; Metal

This project has as its long-term goal the development of chemosensing molecules that bind metal ions and signal specific metal ion binding. The specific aims of this study are to design and synthesize peptide derived macrocyclic ligands with an intrinsic fluorescent signal to indicate metal ion binding. The strategy is to employ peptide based macrocycles incorporating intrinsic signalling molecules that display a fluorescence response. The ion binding selectivities will be comparatively studied by NMR, CD, potentiometry and fluorescence techniques. Ground state properties of these macrocycles, in the solid state as well as in solution, will be investigated by X-ray diffraction methods, NMR and conformational analysis.With this Award, the Organic and Macromolecular Chemistry Program's Organic Dynamics Program supports the research of Professor Maria Ngu-Schwemlein of Southern University. Professor Ngu-Schwemlein proposes to study the interactions between metal ions and small molecules that are modeled on proteins. With a detectable interaction between these molecules and specific ions, applications toward ion selective sensors, ion chromatography, and metal ion detoxification will be possible.

该项目的长期目标是开发结合金属离子和信号特异性金属离子结合的化学传感分子。本研究的具体目的是设计和合成具有内禀荧光信号指示金属离子结合的肽衍生大环配体。该策略是采用基于肽的大环结合固有的信号分子，显示荧光响应。离子结合选择性将通过核磁共振、CD、电位测定和荧光技术进行比较研究。这些大环在固态和溶液中的基态性质将通过x射线衍射方法、核磁共振和构象分析进行研究。通过这个奖项，有机和大分子化学项目的有机动力学项目支持了南方大学Maria nung - schwemlein教授的研究。nung - schwemlein教授建议研究以蛋白质为模型的金属离子和小分子之间的相互作用。随着这些分子和特定离子之间可检测到的相互作用，应用于离子选择传感器、离子色谱和金属离子解毒将成为可能。