POWRE: Enzyme-Substrate Interactions Mediated by Vitamin B6

POWRE：维生素 B6 介导的酶-底物相互作用

• 批准号: 0074574
• 负责人: Mary Jo Ondrechen
• 金额: $ 7.5万
• 依托单位: Northeastern University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-07-01 至 2002-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0074574&HistoricalAwards=false
• 关键词: POWRE; Enzyme; Substrate; Interactions; Mediated

OndrechenThis POWRE award is for a 15 month sabbatical for the PI at Brandeis University, working with Professor Dagmar Ringe's group on enzymatic systems that use pyridoxal phosphate (Vitamin B6) as a cofactor. A quantum mechanical-molecular mechanical model for enzyme-substrate interactions will be developed and applied to the vitamin B6-dependent enzymes alanine racemase and D-amino acid aminotransferase. This project will enable the PI to expand her knowledge in the biochemical and biomedical areas and develop a research program in these areas. The project is also designed to enhance our understanding of how enzymes perform their functions as catalysts.

Ondrechen这个POWRE奖是为布兰迪斯大学PI提供15个月的休假，与Dagmar林格教授的小组一起研究使用磷酸吡哆醛（维生素B6）作为辅因子的酶系统。 将开发酶-底物相互作用的量子力学-分子力学模型，并将其应用于维生素B6依赖酶丙氨酸消旋酶和D-氨基酸转氨酶。 该项目将使PI扩展她在生物化学和生物医学领域的知识，并在这些领域制定研究计划。 该项目还旨在提高我们对酶如何发挥催化剂功能的理解。