POWRE: Molecular Control of Interfaces in Insitu Polymer-Hydroxyapatite Composites for Bone Replacement

[00:74662]在寻找骨替代新材料的过程中，设计具有与骨相似机械性能的复合材料，以避免与当前涂层金属植入物相关的周围骨的应力屏蔽等问题，是人们感兴趣的。该POWRE奖的重点是研究控制原位羟基磷灰石(HAP)-聚合物复合材料的机械性能的方法，以实现其作为骨替代品的潜在用途。有机化合物对无机相结晶的分子控制在制造新复合材料方面具有广泛的应用前景。离子聚合物，如聚丙烯酸（PAAc）是合适的，因为他们的能力强结合钙离子。本研究的主要目的是确定羟基磷灰石矿化过程中羟基磷灰石与聚合物添加剂之间的基本分子相互作用。这将允许控制HAP的微观结构演变，从而观察原位HAP/聚合物复合材料的力学行为。具体的研究目标是：1。发展对聚合物-羟基磷灰石原位复合材料中有机相和无机相分子水平相互作用的基本理解。离子聚合物链在微晶聚集体形成和HAP成核生长中的具体作用将被研究。2. 将分子参数（如振动带强度变化和移位）与宏观力学行为（如拉伸和压缩强度）相关联。PI是新大的新教员。power资助将帮助她建立一个独立的研究项目，并进一步发展她的职业生涯。这笔拨款将帮助PI开发第一个研究计划，在NDSU建立生物材料研究和教育计划。PI建议将生物材料领域的研究与教育结合起来，让本科生和/或少数民族学生积极参与研究。在拟议的研究结束时，PI计划将研究结果整合到生物材料新课程的开发中。本课程主要针对高年级和研究生工程专业的学生，并将促进生物材料在新大工程界的重要性

0074662KattiIn the quest for new materials for bone replacement, it is of interest to design composites with mechanical properties similar to that of bone to avoid problems such as stress shielding of surrounding bone that are associated with the current coated metallic implants. The focus of this POWRE award is to investigate means of controlling mechanical properties in insitu hydroxyapatite(HAP)-polymer composites for their potential use as bone replacement. A molecular control of crystallization of inorganic phases by organic compounds has shown great promise for fabrication of new composites for several applications. Ionic polymers such as poly(acrylic acid) (PAAc) are suitable due to their ability to strongly bind Ca ions. The major aim of the proposed research is to identify and determine fundamental molecular interactions between HAP and polymeric additive during mineralization of HAP. This will allow for a control of microstructural evolution of HAP and hence the observed mechanical behavior in insitu HAP/polymer composites. The specific research objectives are: 1. To develop a fundamental understanding of molecular level interactions of organic and inorganic phases in polymer-hydroxyapatite insitu composites. The specific role of ionic polymer chains on microcrystalline aggregate formation and nucleation and growth of HAP will be investigated. 2. Correlate molecular parameters (such as vibrational band intensity changes and shifts) to macroscopic mechanical behavior such as tensile and compressive strengths. The PI is a new faculty at NDSU. The POWRE grant will help her establish an independent research program and further her career development. This grant will help the PI to develop a first research initiative to establish a Biomaterials research and education program at NDSU. The PI proposes to integrate research with education in the Biomaterials field by involving undergraduate women and/or minority students into active research. At the conclusion of the proposed studies, the PI plans to integrate results of the study into development of a new course on Biomaterials. This course will be focussed towards senior level and graduate engineering students and will promote the importance of Biomaterials in the engineering community at NDSU.***