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CAREER: Research and Education: Biomimetic Routes to Design of Biomaterials

职业：研究和教育：生物材料设计的仿生途径

基本信息

批准号：
0132768
负责人：
Kalpana Katti
金额：
$ 37.5万
依托单位：
North Dakota State University Fargo
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2002
资助国家：
美国
起止时间：
2002-02-15 至 2008-01-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=0132768&HistoricalAwards=false
关键词：
CAREER Research Education Biomimetic Routes

项目摘要

Research and educational activities tied to biomaterials and bio-inspired materials are the theme of the career plan of the PI. A fundamental approach is followed towards design of composites of hydroxyapatite and polymers for development of new biomaterials for bone replacement. The new approach takes inspiration from biology. A molecular control of polymer-HAP interactions is attempted with synthetic macromolecules, mimicking the formation of biocomposites in nature. Experiments will involve vibrational microspectroscopy and scanning electron microscopy to elucidate the molecular interactions between polymeric additives and mineral components under simulated body fluid environments. These interactions and understanding their role on bulk macroscopic mechanical response of the composite to loading is the focus of these studies. This research will attempt to understand the molecular mechanisms involved in formation of insitu composites and develop fundamental science based on this understanding to design composites with properties tailored for bone replacement. The educational activities proposed are very closely linked to the research. PI plans to 1.) Improve awareness of the biomaterials field at NDSU through a new course on biomaterials, summer research projects for undergraduate students and establishing a NDSU chapter of Materials Research Society. 2.) Stimulate interest in engineering and materials related research in middle school girls and 3.) Bring excitement of the materials and biomaterials field into middle school classrooms.

与生物材料和生物启发材料相关的研究和教育活动是PI职业规划的主题。羟基磷灰石和聚合物复合材料的设计是开发新型骨替代生物材料的基本方法。这种新方法的灵感来自生物学。聚合物- hap相互作用的分子控制尝试与合成大分子，模仿生物复合材料在自然界的形成。实验将涉及振动显微光谱和扫描电子显微镜，以阐明在模拟体液环境下聚合物添加剂和矿物组分之间的分子相互作用。这些相互作用以及了解它们在复合材料对载荷的宏观力学响应中的作用是这些研究的重点。本研究将试图了解原位复合材料形成的分子机制，并在此基础上发展基础科学，以设计具有骨替代特性的复合材料。提出的教育活动与研究密切相关。PI计划1。1 .通过开设生物材料新课程、开展本科生暑期研究项目、建立材料研究会分会等措施，提高学生对生物材料领域的认识。激发中学女生对工程和材料相关研究的兴趣。将材料和生物材料领域的兴奋带入中学课堂。