Interdisciplinary Grant in the Mathematical Sciences: Models of Hippocampal Neuron Activity

该基金支持应用数学和神经生物学的跨学科研究项目。具体来说，PI将用一个学年的假期访问西北大学的神经生物学和生理学系。这个跨学科研究项目的目标是：1)参与并协助正在进行的海马神经元实验的建模；2)利用专注的学习环境培养对神经生物学的充分理解和在该领域继续研究所需的技能；3)创建可以作为PI所在部门的研究生和本科生课程的一部分的材料。要研究的具体问题包括海马CA1锥体神经元缓慢累积的钠通道失活的建模，以及对海马下神经元破裂原因的研究。为了确保项目的成功，在整个工作期间，PI将由其他熟悉数学在生物学中的应用的研究人员向外部提供建议。该IGMS项目由MPS多学科活动办公室（OMA）和数学科学司（DMS）联合支持。

This grant supports an interdisciplinary research project in applied mathematics and neurobiology. Specifically, the PI will spend an academic year leave visiting the Department of Neurobiology and Physiology at Northwestern University. The goal of this interdisciplinary research program is: 1) to participatein and assist with the modeling of ongoing experiments on hippocampal neurons; 2) to use the focused learning environment to develop a sufficient understanding of neurobiology and the skills necessary for continued research in this area; 3) to create materials that can be used as part of the graduate andundergraduate curricula in the PI's home department. Specific problems to be examined include the modeling of slow, cumulative sodium channel inactivation in hippocampal CA1 pyramidal neurons, and a study of the causes of bursting in subicular hippocampal neurons. To help ensure the project's success, the PI will beexternally advised throughout the duration of the work by other researchers familiar with the application of mathematics to biology. This IGMS project is jointly supported by the MPS Office of Multidisciplinary Activities (OMA) and the Division of Mathematical Sciences (DMS).