Interdisciplinary Grant in the Mathematical Sciences: Models of Hippocampal Neuron Activity

这笔赠款支持应用数学和神经生物学的一个跨学科研究项目。具体地说，PI将花一学年的时间去西北大学神经生物学和生理学系访问。这一跨学科研究计划的目标是：1)参与并协助正在进行的海马神经元实验的建模；2)利用专注的学习环境来发展对神经生物学的充分了解，以及在该领域继续研究所需的技能；3)创建可作为PI国内系研究生和本科生课程的一部分的材料。要研究的具体问题包括：对海马区CA1区锥体神经元缓慢累积的钠通道失活进行建模，以及研究海马区下丘脑神经元爆发的原因。为了帮助确保项目的成功，在整个工作过程中，PI将得到其他熟悉将数学应用于生物学的研究人员的外部建议。该IGMS项目由重大计划多学科活动办公室(OMA)和数学科学处(DMS)共同支持。

This grant supports an interdisciplinary research project in applied mathematics and neurobiology. Specifically, the PI will spend an academic year leave visiting the Department of Neurobiology and Physiology at Northwestern University. The goal of this interdisciplinary research program is: 1) to participatein and assist with the modeling of ongoing experiments on hippocampal neurons; 2) to use the focused learning environment to develop a sufficient understanding of neurobiology and the skills necessary for continued research in this area; 3) to create materials that can be used as part of the graduate andundergraduate curricula in the PI's home department. Specific problems to be examined include the modeling of slow, cumulative sodium channel inactivation in hippocampal CA1 pyramidal neurons, and a study of the causes of bursting in subicular hippocampal neurons. To help ensure the project's success, the PI will beexternally advised throughout the duration of the work by other researchers familiar with the application of mathematics to biology. This IGMS project is jointly supported by the MPS Office of Multidisciplinary Activities (OMA) and the Division of Mathematical Sciences (DMS).