Interdisciplinary Grant in the Mathematical Sciences: Models of Hippocampal Neuron Activity

数学科学跨学科资助：海马神经元活动模型

• 批准号: 0075109
• 负责人: William Kath
• 金额: $ 9.76万
• 依托单位: Northwestern University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-15 至 2002-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0075109&HistoricalAwards=false
• 关键词: Interdisciplinary; Grant; Mathematical; Sciences; Models

This grant supports an interdisciplinary research project in applied mathematics and neurobiology. Specifically, the PI will spend an academic year leave visiting the Department of Neurobiology and Physiology at Northwestern University. The goal of this interdisciplinary research program is: 1) to participatein and assist with the modeling of ongoing experiments on hippocampal neurons; 2) to use the focused learning environment to develop a sufficient understanding of neurobiology and the skills necessary for continued research in this area; 3) to create materials that can be used as part of the graduate andundergraduate curricula in the PI's home department. Specific problems to be examined include the modeling of slow, cumulative sodium channel inactivation in hippocampal CA1 pyramidal neurons, and a study of the causes of bursting in subicular hippocampal neurons. To help ensure the project's success, the PI will beexternally advised throughout the duration of the work by other researchers familiar with the application of mathematics to biology. This IGMS project is jointly supported by the MPS Office of Multidisciplinary Activities (OMA) and the Division of Mathematical Sciences (DMS).

该补助金支持应用数学和神经生物学的跨学科研究项目。 具体来说，PI将花一个学年的假期访问西北大学神经生物学和生理学系。 这个跨学科研究计划的目标是：1）参与并协助正在进行的海马神经元实验的建模; 2）使用集中的学习环境来发展对神经生物学的充分理解和在这一领域继续研究所需的技能; 3）创建可以用作PI家庭部门研究生和本科生课程的一部分的材料。 具体的问题要检查包括建模缓慢，累积的钠通道失活在海马CA 1区锥体神经元，和海马下托神经元爆裂的原因的研究。为了帮助确保项目的成功，PI将在整个工作期间由其他熟悉数学应用于生物学的研究人员提供外部建议。 该IGMS项目由MPS多学科活动办公室（OMA）和数学科学部（DMS）共同支持。