Upgrade of NMR Equipment at East Carolina University

东卡罗莱纳大学核磁共振设备升级

• 批准号: 0077988
• 负责人: Chia-yu Li
• 金额: $ 20.83万
• 依托单位: East Carolina University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0077988&HistoricalAwards=false
• 关键词: Upgrade; NMR; Equipment; East; Carolina

With this award from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at the East Carolina University will acquire a 300 MHz NMR and upgrade a 200 MHz NMR spectrometer. This equipment will enable researchers to carry out studies on a) development of new reagents for the kinetic resolution of chiral alcohols; b) the study of a one-step stereoselective approach to polycyclic ring systems possessing multiple stereogenic centers as a model for biomimetic-like cyclization processes; c) studies of bleomycin-DNA binding; d) synthesis and coordination chemistry of new classes of macrocyclic ligands;and e) investigations of the rotational dynamics of fullerenes. The upgraded instrument will also be used in a number of advanced laboratory courses. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in a number of areas including materials chemistry, catalysis, sensor development and medicine .

有了化学研究仪器和设施(CRIF)计划的这一奖项，东卡罗来纳大学化学系将购买一台300 MHz核磁共振，并升级一台200 MHz核磁共振光谱仪。该设备将使研究人员能够开展以下研究：a)开发用于手性醇的动力学拆分的新试剂；b)具有多个立体中心的多环环系统的一步立体选择方法作为仿生环化过程的模型；c)博莱霉素与DNA的结合研究；d)新型大环配体的合成和配位化学；以及e)富勒烯的旋转动力学研究。升级后的仪器还将用于一些高级实验室课程。核磁共振波谱是化学家用来解释分子结构的最有力的工具。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱是必不可少的。这些核磁共振研究的结果将对材料化学、催化、传感器开发和医学等多个领域产生影响。