Upgrade of NMR Equipment at East Carolina University

凭借化学研究仪器和设施（CRIF）计划的这一奖项，东卡罗莱纳大学化学系将获得300 MHz NMR并升级200 MHz NMR光谱仪。该设备将使研究人员能够进行以下研究：a）开发手性醇动力学拆分的新试剂; B）研究具有多个立体中心的多环体系的一步立体选择性方法，作为仿生环化过程的模型; c）研究博来霉素-DNA结合; d）新型大环配体的合成和配位化学;和e）富勒烯的旋转动力学的研究。 升级后的仪器还将用于一些高级实验室课程。 核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。 对于从事前沿研究的化学家来说，使用最先进的NMR光谱分析技术是必不可少的。这些NMR研究的结果将在许多领域产生影响，包括材料化学，催化，传感器开发和医学。

With this award from the Chemistry Research Instrumentation and Facilities (CRIF) Program, the Department of Chemistry at the East Carolina University will acquire a 300 MHz NMR and upgrade a 200 MHz NMR spectrometer. This equipment will enable researchers to carry out studies on a) development of new reagents for the kinetic resolution of chiral alcohols; b) the study of a one-step stereoselective approach to polycyclic ring systems possessing multiple stereogenic centers as a model for biomimetic-like cyclization processes; c) studies of bleomycin-DNA binding; d) synthesis and coordination chemistry of new classes of macrocyclic ligands;and e) investigations of the rotational dynamics of fullerenes. The upgraded instrument will also be used in a number of advanced laboratory courses. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies will have an impact in a number of areas including materials chemistry, catalysis, sensor development and medicine .