Equipment: MRI: Track 1 Acquisition of a 600 MHz NMR with Cryoprobe for the Greater Rocky Mountain Region

设备： MRI：轨道 1 为大落基山脉地区采购带有冷冻探针的 600 MHz NMR

• 批准号: 2320158
• 负责人: Brian Michel
• 金额: $ 139.77万
• 依托单位: University of Denver
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2320158&HistoricalAwards=false
• 关键词: Equipment; MRI; Track; Acquisition; 600

An award is made to the University of Denver to acquire a state-of-the-art 600 MHz Nuclear Magnetic Resonance (NMR) spectrometer with a Cryoprobe and a cooled SampleCase. This instrument will support researchers at the University of Denver and across the greater Rocky Mountain region, enabling new research ranging from understanding biomolecular interactions to characterizing functional tools in complex biological systems. This project will support modernization of curricular activities in undergraduate (Organic lab sequence, Instrumental Analysis, and Frontiers in Chemistry) and graduate courses (Organic Spectroscopy and Biophysical Methods), greatly increasing the number of students exposed modern 2D and multinuclear NMR experiments. High-school, undergraduate, graduate, and postdoctoral researchers will benefit from training on state-of-the-art equipment. This includes students in the SHINE@DU program, which provides paid 8-week summer internships to local junior and senior high-school students largely from groups underrepresented in the sciences. This project will benefit the citizen science Foldit game, which will continue to improve via validation of solved structures. Responsible stewardship and conservation of finite helium resources will continue through helium recovery and recycling at the University of Denver.The new instrument will enable biomolecular and chemical research owing to increased sensitivity, resolution, transceiver capability, and access that is not currently possible at the University of Denver and is severely limited in the region. This NMR will enable biomolecular researchers to (1) understand how nucleic acids interact with proteins to inhibit aggregation, (2) investigate the mechanism of how synthetic protein mimics modulate aberrant protein-protein interactions, and (3) discover and characterize novel metallophores. Chemical biology and chemical researchers will use the new NMR spectrometer to: (1) elucidate the structures of complex polyheterocycles, (2) characterize and investigate organometallic complexes as tools for probing biological systems, and (3) identify and analyze end-groups of functional linear polymers. A number of regional users, including researchers at primarily undergraduate institutions and area start-up companies, will have remote and in-person access to the new NMR.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

丹佛大学获得了最先进的600 MHz核磁共振（NMR）光谱仪，该光谱仪带有冷冻探针和冷却样品箱。该仪器将支持丹佛大学和整个大落基山脉地区的研究人员，使新的研究范围从理解生物分子相互作用到表征复杂生物系统中的功能工具。本项目将支持本科生（有机实验序列、仪器分析和化学前沿）和研究生课程（有机光谱学和生物物理方法）的课程活动现代化，大大增加学生接触现代二维和多核磁共振实验的人数。高中、本科、研究生和博士后研究人员将受益于最先进设备的培训。这包括参加SHINE@DU项目的学生，该项目为当地初高中学生提供为期8周的带薪暑期实习，这些学生大多来自科学领域代表性不足的群体。该项目将使公民科学Foldit游戏受益，该游戏将通过验证已解决的结构继续改进。负责任的管理和保护有限的氦气资源将继续通过氦气回收和循环利用在丹佛大学。由于提高了灵敏度、分辨率、收发能力和接入能力，新仪器将使生物分子和化学研究成为可能，这在丹佛大学目前是不可能的，而且在该地区受到严重限制。这种核磁共振将使生物分子研究人员能够(1)了解核酸如何与蛋白质相互作用以抑制聚集，(2)研究合成蛋白质模拟物如何调节异常蛋白质-蛋白质相互作用的机制，以及(3)发现和表征新的金属基团。化学生物学和化学研究人员将使用新的核磁共振波谱仪：(1)阐明复杂多杂环的结构；(2)表征和研究有机金属配合物作为探测生物系统的工具；(3)识别和分析功能线性聚合物的端基。许多地区用户，包括主要是本科院校和地区初创公司的研究人员，将可以远程和亲自访问新的NMR。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。