Zirconocenes in Organic Synthesis

有机合成中的锆茂

• 批准号: 0078944
• 负责人: Peter Wipf
• 金额: $ 34.8万
• 依托单位: University of Pittsburgh
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0078944&HistoricalAwards=false
• 关键词: Zirconocenes; Organic; Synthesis

The goals of this research are: (a) The development of new, improved ligands for asymmetric Zr-Zn transmetalation-carbonyl addition reactions. (b) The use of zirconocene methodology for the total synthesis of lophotoxin. (c) The development of a catalytic asymmetric conjugate addition protocol for organozirconocenes using chiral Cu(I) complexes. (d) The study and synthetic applications of the water acceleration effect in the asymmetric carboalumination reaction of alkenes using chiral zirconocene dichlorides. (e) The study of epoxide opening cascades mediated by cationic zirconocenes that can lead to linked and fused tetrahydronfurans and pyrans of interest to polyether natural product synthesis.With this award, the Organic and Macromolecular Chemistry Program is supporting thre Research of Dr. Peter Wipf of the Department of Chemistry at the University of Pittsburgh. Professor Wipf will focus his work on developing new zirconocene-based methodology for applications in organic synthesis, including the total synthesis of natural products. The work has broader impacts for the pharmaceutical and agricultural industries.

本研究的目标是：（a）开发新的，改进的配体用于不对称Zr-Zn金属转移-羰基加成反应。(b)利用二茂锆方法全合成碘光辛。(c)手性Cu（I）配合物催化有机二茂锆的不对称共轭加成反应。(d)手性二氯二茂锆在烯烃不对称碳铝化反应中的水促进效应研究及合成应用。(e)对由阳离子二茂锆介导的环氧化物开环级联反应的研究，该反应可导致对聚醚天然产物合成感兴趣的连接和稠合的四氢呋喃和吡喃。有了这个奖项，有机和大分子化学计划支持匹兹堡大学化学系的Peter Wipf博士的研究。 Wipf教授将专注于开发新的基于二茂锆的方法学，用于有机合成，包括天然产物的全合成。 这项工作对制药和农业行业产生了更广泛的影响。