Zirconocenes in Organic Synthesis

有机合成中的锆茂

• 批准号: 0315205
• 负责人: Peter Wipf
• 金额: $ 38.52万
• 依托单位: University of Pittsburgh
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-01 至 2006-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0315205&HistoricalAwards=false
• 关键词: Zirconocenes; Organic; Synthesis

The focus of this research involves the development of asymmetric synthetic methods centered on new protocols for sequential zirconium to zinc transmetalation-carbonyl and -imine additions, including catalytic asymmetric methods and chiral auxiliaries. Further, the study of the chemistry of C-cyclopropylalkylamines and the the preparative extension of the water-acceleration effect in Zr/Al cascade reactions will be carried out.With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. Peter Wipf in the Department of Chemistry at the University of Pittsburgh. Dr. Wipf will focus his work on developing methodology for asymmetric synthesis using the intermediacy of organometallic compounds known as zirconocenes. The strategy takes advantage of the availability and ease of handling of alkenes and alkynes as precursors for stereoselective C-C and C-heteroatom bond formation. The broader impact of the work is in the areas of pharmaceutical and agricultural chemistry. Further, the project presents an excellent venue for the training of graduate students and postdoctorals.

本研究的重点涉及不对称合成方法的发展集中在新的协议顺序锆锌transmetalation-carbonyl和-imine加成，包括催化不对称方法和手性助剂。 此外，还将开展C-环丙基烷基胺的化学研究和Zr/Al级联反应中水加速效应的制备扩展。有了这个奖项，有机和大分子化学计划将支持匹兹堡大学化学系Peter Wipf博士的研究。 Wipf博士将专注于开发使用被称为二茂锆的有机金属化合物的中间体进行不对称合成的方法。 该策略利用了烯烃和炔作为立体选择性C-C和C-杂原子键形成的前体的可用性和易于处理性。这项工作的更广泛影响是在制药和农业化学领域。 此外，该项目为研究生和博士后的培训提供了一个很好的场所。