Acquisition of In-Line Analytical and Automated Purification Instrumentation

在化学研究仪器和设施(CRIF)和主要研究仪器(MRI)计划的支持下，匹兹堡大学化学系将获得一台500 MHz核磁共振(核磁共振)光谱仪，这是在线分析和自动化净化仪器设施的一个组件。这将使教师能够协调组合合成和方法开发与严格的纯化和常规的高水平核磁共振分析，这对有机化学中的质量控制非常重要。具体研究课题包括：从丙烯酰胺水凝胶中聚合的晶体胶体阵列制备智能材料；开发合成天然产物的新合成路线；机械性有机化学；发现和优化具有生物活性的有机小分子；用于固相有机合成的微型反应器的开发和利用；组合合成策略的开发；用于非常选择性萃取的人造受体的开发；利用异构体之间溶解度差异的化学产品分离和提纯的新方法；磷酸酶抑制剂文库的固相平行合成；磷酸酶抑制剂文库的氟相平行合成；烯烃多肽等位体文库的合成；以及用于固相组合化学的新型间隔物的合成和评价。核磁共振波谱是化学家用来解释分子结构的最有力的工具。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱是必不可少的。这些核磁共振研究的结果在聚合物、催化和生物学等领域都是有用的。

With support from the Chemistry Research Instrumentation and Facilities (CRIF) and Major Research Instrumentation (MRI) Programs, the Department of Chemistry at the University of Pittsburgh will acquire a 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer, a component of an In-Line Analytical and Automated Purification Instrumentation Facility. This will allow the faculty to coordinate combinatorial synthesis and method development with the strict purification and routine high level NMR analysis that is important for quality control in organic chemistry. Specific research topics include the preparation of smart materials from crystalline colloidal arrays polymerized in acrylamide hydrogels; development of new synthetic routes to natural products; mechanistic organic chemistry; discovery and optimization of biologically active small organic molecules; development and use of micro-reactors for solid phase organic synthesis; use of combinatorial synthesis strategies for development of polymetallic catalysts; development of artificial receptors for very selective extractions; new approaches to chemical product isolation and purification that exploit differences in solubilities between isomers; solid phase parallel synthesis of libraries of phosphatase inhibitors; fluorous phase parallel synthesis of libraries of phosphatase inhibitors; synthesis of libraries of alkene peptide isosteres; and synthesis and evaluation of new spacers for solid phase combinatorial chemistry. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies are useful in the areas such as polymers, catalysis, and in biology.