Acquisition of In-Line Analytical and Automated Purification Instrumentation

收购在线分析和自动纯化仪器

• 批准号: 9977378
• 负责人: Peter Wipf
• 金额: $ 42万
• 依托单位: University of Pittsburgh
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9977378&HistoricalAwards=false
• 关键词: Acquisition; Line; Analytical; Automated; Purification

With support from the Chemistry Research Instrumentation and Facilities (CRIF) and Major Research Instrumentation (MRI) Programs, the Department of Chemistry at the University of Pittsburgh will acquire a 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer, a component of an In-Line Analytical and Automated Purification Instrumentation Facility. This will allow the faculty to coordinate combinatorial synthesis and method development with the strict purification and routine high level NMR analysis that is important for quality control in organic chemistry. Specific research topics include the preparation of smart materials from crystalline colloidal arrays polymerized in acrylamide hydrogels; development of new synthetic routes to natural products; mechanistic organic chemistry; discovery and optimization of biologically active small organic molecules; development and use of micro-reactors for solid phase organic synthesis; use of combinatorial synthesis strategies for development of polymetallic catalysts; development of artificial receptors for very selective extractions; new approaches to chemical product isolation and purification that exploit differences in solubilities between isomers; solid phase parallel synthesis of libraries of phosphatase inhibitors; fluorous phase parallel synthesis of libraries of phosphatase inhibitors; synthesis of libraries of alkene peptide isosteres; and synthesis and evaluation of new spacers for solid phase combinatorial chemistry. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies are useful in the areas such as polymers, catalysis, and in biology.

在化学研究仪器和设施（CRIF）和主要研究仪器（MRI）计划的支持下，匹兹堡大学化学系将获得一台500 MHz核磁共振（NMR）光谱仪，这是在线分析和自动纯化仪器设施的一个组成部分。 这将使教师能够协调组合合成和方法开发与严格的纯化和常规的高水平NMR分析，这是重要的有机化学质量控制。 具体的研究课题包括从丙烯酰胺水凝胶中聚合的晶体胶体阵列制备智能材料;开发天然产物的新合成路线;机械有机化学;发现和优化生物活性小有机分子;开发和使用微反应器进行固相有机合成;使用组合合成策略开发多金属催化剂;用于非常选择性提取的人工受体的开发;利用异构体之间溶解度差异的化学产品分离和纯化的新方法;磷酸酶抑制剂文库的固相平行合成;磷酸酶抑制剂文库的氟相平行合成;烯烃肽电子等排体文库的合成;以及用于固相组合化学的新型间隔基的合成和评价。 核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱分析技术是必不可少的。这些NMR研究的结果在聚合物、催化和生物学等领域都很有用。