Acquisition of a Microarray Facility

收购微阵列设施

• 批准号: 0079375
• 负责人: Desmond Smith
• 金额: $ 20.38万
• 依托单位: University of California-Los Angeles
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0079375&HistoricalAwards=false
• 关键词: Acquisition; Microarray; Facility

An integrated microarraying facility will be initiated in the Department of Molecular and Medical Pharmacology (DMMP) in the Center for Health Sciences (CHS) at UCLA. The facility will consist of a DNA processing robot, a microarrayer, a scanner, a DNA/clone resource, and a computational facility. The microarray facility has been designed to provide the highest practicable throughput of this powerful technology.The research will cover the whole range of modern biology including studies of retroviruses, differentiation of neural stem cells and other cells, the cellular response to metals, synaptic transmission, neural growth factors, nitrous oxide physiology, immune system differentiation, neural aspects of behavior and glucocorticoid signaling. An important part is to improve the bioinformatics of microarray technologies using the data provided by the facility.This facility will provide researchers and their students the ability to visualize gene expression patterns for thousands of genes at once and have a major impact on research in cell and molecular biology at UCLA.

加州大学洛杉矶分校健康科学中心（CHS）的分子和医学药理学系（DMMP）将启动一个集成的微阵列设施。该设施将包括一个DNA处理机器人，一个微阵列，一个扫描仪，一个DNA/克隆资源，和一个计算设施。这项研究将涵盖现代生物学的各个领域，包括逆转录病毒、神经干细胞和其他细胞的分化、细胞对金属的反应、突触传递、神经生长因子、一氧化二氮生理学、免疫系统分化、神经行为和糖皮质激素信号等。一个重要的部分是使用该设施提供的数据来改进微阵列技术的生物信息学。该设施将为研究人员和他们的学生提供同时可视化数千个基因的基因表达模式的能力，并对加州大学洛杉矶分校的细胞和分子生物学研究产生重大影响。