Design and implementation of monolithic integrated electronic devices for the control and recordingof bidirectional multi-electrode arrays.

用于控制和记录双向多电极阵列的单片集成电子器件的设计和实现。

• 批准号: 143692466
• 负责人: Professor Dr. Anton Grabmaier
• 金额: --
• 依托单位: Fachgebiet Elektronische Bauelemente und Schaltungen (EBS)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2011
• 资助国家: 德国
• 起止时间: 2010-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/143692466?language=en
• 关键词: Design; implementation; monolithic; integrated; electronic

The research project investigates the possibility of simultaneously stimulating and recording neural cells of the retina. This will be achieved by a multi-electrode array (MEA) that penetrates through all layers of the retina. The MEAs designed within this project will have more than one electrode per penetrating shank. Each electrode can be selected as either a stimulating or recording electrode, thereby allowing simultaneous stimulation and recording within a small area of tissue. From an engineering perspective it can present a breakthrough in the design of better implants due to the possibility of stimulation of different depths of tissue. An automatic stimulation parameter adaption based on the analyzed tissue will be possible. In the first phase of the project, the much reduced size of the electrodes in the MEA has proven that well-known stimulation techniques cannot be used without causing damage. A new stimulation technique has been invented to circumvent this problem and to permit safe stimulation of the retina using MEAs with small area electrodes. As required by the general project description, the new stimulation method is specifically designed to target retinal bipolar cells.The objectives of the proposed second phase of the project are firstly to complete the functional verification of the recording and stimulation chips, received at the end of the first funding phase, together with the current electrode array. Secondly, the generation of arbitrary stimulation signals will be included into the new stimulation technique and implemented in the new stimulator IC. The results of cell-biologic experiments on different cell layers, elaborated by our partners, will form the base for the specification of the new stimulator chip. Thirdly, together with the biomedical experimenters of subproject C and D the following questions will to be investigated:- Is it possible to stimulate different types of retinal nerve cells using the new stimulation technique and record their activity simultaneously? Is it also possible to limit the stimulation space parameters or to adapt the modulation concept during stimulation?- Are there any layer-specific stimulus waveforms and parameters which result in best behavior in relation to layer and place? What ist the best way of generating these waveforms?The results will guide the design of a CMOS-chip which performs the arbitrary stimulation as well as the recording functionality. During the project subgroup A will implemented this chip with a two dimensional basic structure for four penetrating shanks. It will be provided to subgroups C and D as a multi parameter configuration test board during the last third of the project.

该研究项目探讨了同时刺激和记录视网膜神经细胞的可能性。这将通过穿透视网膜所有层的多电极阵列（MEA）来实现。本项目中设计的mea每个穿透杆将有多个电极。每个电极可以选择作为刺激电极或记录电极，从而允许在小面积组织内同时进行刺激和记录。从工程学的角度来看，由于可以刺激不同深度的组织，它可以在设计更好的植入物方面取得突破。基于分析组织的自动刺激参数适应将成为可能。在项目的第一阶段，MEA中电极的尺寸大大减小，证明了众所周知的增产技术不可能在不造成损害的情况下使用。一种新的刺激技术已经被发明来规避这个问题，并允许使用小面积电极的mea对视网膜进行安全刺激。根据总体项目描述的要求，新的刺激方法是专门针对视网膜双极细胞设计的。该项目第二阶段的目标是首先完成记录和刺激芯片的功能验证，这些芯片在第一个资助阶段结束时收到，以及当前的电极阵列。其次，将任意刺激信号的产生纳入新的刺激技术，并在新的刺激器IC中实现。我们的合作伙伴详细阐述的不同细胞层的细胞生物学实验结果将构成新的刺激器芯片规格的基础。第三，与子项目C和D的生物医学实验人员一起研究以下问题：-是否有可能使用新的刺激技术刺激不同类型的视网膜神经细胞并同时记录其活动？是否也有可能限制增产空间参数或在增产过程中采用调制概念？-是否存在特定于层的刺激波形和参数，从而导致与层和位置相关的最佳行为？产生这些波形的最佳方法是什么？研究结果将为实现任意刺激和记录功能的cmos芯片的设计提供指导。在项目期间，A小组将实现该芯片，该芯片具有四个穿透柄的二维基本结构。在项目的最后三分之一，作为多参数配置测试板提供给C和D子组。