U. S. Germany Cooperative Research: Lateral Mobility of Transmembrane Proteins in Polymer-tethered Phospholipid Bilayers Studied Via Single Molecule Fluorescence Imaging

0089604诺曼该奖项支持克里斯托夫·诺曼和普渡印第安纳大学的学生与德国慕尼黑马克斯·普朗克生物化学研究所的伊娃-凯瑟琳·施密特合作。研究的重点是开发合适的人工膜结构，以便研究编码蛋白质的特定相互作用。一旦人类基因组被绘制出来，对这类研究的需求将会很大。该项目利用了美国和德国小组的互补设施和专业知识：美方提供了关于最先进的跨膜蛋白膜结构的详细知识，以及进行相关测量所需的设备；德国方面拥有与研究中使用的跨膜蛋白的制备和表征相关的专业知识。这一联合合作研究工作也为初级研究人员提供了在国际上工作的机会，就这一提议所做的工作将有助于使德国和美国研究小组之间的关系制度化。

0089604NaumannThis award supports Christoph Naumann and students from Indiana University-Purdue in a collaboration with Eva-Kathrin Schmidt of the Max Planck Institute for Biochemistry in Munich, Germany. The research focus is on development of appropriate artificial membrane architectures to allow studies of specific interactions of encoded proteins. There will be a great demand for such studies once the human genome has been mapped. This project uses the complementary facilities and expertise of the U.S. and German groups: the U.S. side provides detailed knowledge about state-of-the-art membrane architectures for transmembrane proteins and the equipment necessary to make pertinent measurements; the German counterpart has expertise related to the preparation and characterization of the transmembrane proteins to be used in the research. This joint collaborative research effort also presents junior researchers with the opportunity to work internationally, and the work done on this proposal will help institutionalize the relationship between the German and U.S. research groups.