Differential, dynamic syndapin complexes - modulators of membrane topology and transport

差异、动态联苯酚复合物 - 膜拓扑和运输的调节剂

• 批准号: 144593600
• 负责人: Professorin Dr. Britta Qualmann
• 金额: --
• 依托单位: Institut für Biochemie I
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2009
• 资助国家: 德国
• 起止时间: 2008-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/144593600?language=en
• 关键词: Differential; dynamic; syndapin; complexes; modulators

The plasma membrane, which surrounds eukaryotic cells, separates the cellular interior from the environment. Membrane topology modulation is indispensable for vesicle formation in membrane trafficking processes as well as for establishment, maintenance and plasticity of distinct cellular morphologies - prerequisites for development and live of multicellular organisms. It is catalyzed by the coordinated interplay of direct effectors that bend, tubulate and/or scission membranes and by organization and dynamics of the membrane-associated cortical cytoskeleton. BAR domain superfamily proteins, such as the F-BAR domain proteins of the syndapin family, have emerged as important components in membrane shaping. The project aims at providing further evidence that syndapins, which have the power to imprint their crescent shape onto membranes and furthermore recruit, coordinate and modulate the activity of cellular effectors, are indispensable for shaping cellular membranes and organelles and for the development of cellular structures and whole organisms. The successful realization of the work program is expected to unravel how syndapin-mediated membrane topology control allows for shaping cellular membranes and to reveal the physiological consequences of membrane shaping impairments on individual cellular membrane compartments, on the morphology and function of distinct cell types and on proper function of entire organs and organisms.

包围真核细胞的质膜将细胞内部与环境隔开。膜拓扑结构的调控对于膜运输过程中囊泡的形成以及不同细胞形态的建立、维持和可塑性是必不可少的，这是多细胞生物体发育和生存的先决条件。它是由直接效应物的协调相互作用催化的，这些效应物使膜弯曲、形成管状和/或断裂，并且由膜相关的皮质细胞骨架的组织和动力学催化。BAR结构域超家族蛋白，例如syndapin家族的F-BAR结构域蛋白，已经成为膜成形中的重要组分。该项目旨在提供进一步的证据，证明syndapins能够将其新月形形状印在膜上，并进一步招募，协调和调节细胞效应物的活性，对于塑造细胞膜和细胞器以及细胞结构和整个生物体的发育是不可或缺的。该工作计划的成功实现有望揭示syndapin介导的膜拓扑结构控制如何允许塑造细胞膜，并揭示膜成形损伤对单个细胞膜隔室、不同细胞类型的形态和功能以及整个器官和生物体的正常功能的生理后果。

项目成果

Deciphering caveolar functions by syndapin III KO-mediated impairment of caveolar invagination

• DOI: 10.7554/elife.29854
• 发表时间: 2017-12-05
• 期刊: ELIFE
• 影响因子: 7.7
• 作者: Seemann, Eric;Sun, Minxuan;Qualmann, Britta
• 通讯作者: Qualmann, Britta

The role of membrane-shaping BAR domain proteins in caveolar invagination: from mechanistic insights to pathophysiological consequences.

膜成形 BAR 结构域蛋白在小凹内陷中的作用：从机制见解到病理生理学后果

• DOI: 10.1042/bst20190377
• 发表时间: 2020
• 期刊: Biochemical Society transactions
• 影响因子: 3.9
• 作者: Kessels MM;Qualmann B
• 通讯作者: Qualmann B

Ciliated sensory hair cell formation and function require the F-BAR protein syndapin I and the WH2 domain-based actin nucleator Cobl

• DOI: 10.1242/jcs.111674
• 发表时间: 2013-01
• 期刊: Journal of Cell Science
• 影响因子: 4
• 作者: Susann Schüler;Judith Hauptmann;B. Perner;M. Kessels;C. Englert;B. Qualmann

Regulation of endoplasmic reticulum turnover by selective autophagy

• DOI: 10.1038/nature14498
• 发表时间: 2015-06-18
• 期刊: NATURE
• 影响因子: 64.8
• 作者: Khaminets, Aliaksandr;Heinrich, Theresa;Dikic, Ivan
• 通讯作者: Dikic, Ivan

The functions of the actin nucleator Cobl in cellular morphogenesis critically depend on syndapin I

• DOI: 10.1038/emboj.2011.207
• 发表时间: 2011-08-03
• 期刊: EMBO JOURNAL
• 影响因子: 11.4
• 作者: Schwintzer, Lukas;Koch, Nicole;Qualmann, Britta
• 通讯作者: Qualmann, Britta