Gordon Research Conference on RNA Editing to be held January 21-26, 2001, in Ventura, California

0091286罗纳德B。埃米森和卡莱尔B。关于RNA编辑的StormA Gordon研究会议计划于2001年1月21日至26日在加州文图拉的Doubletree酒店举行。 RNA编辑是RNA的共转录或转录后修饰，其导致核苷酸的插入、缺失或取代。 因此，RNA编辑可以校正、延伸或多样化相应基因组序列内编码的信息，并且可以显著改变修饰的RNA的功能。 例如，哺乳动物中枢神经系统内的编辑事件可以增加神经递质受体表达的多样性，并用于有效地调节神经元信号传导途径。 同样重要的是许多RNA编辑过程的细胞调节，其提供蛋白质功能和生化途径的发育、组织特异性和代谢微调。 对RNA编辑及其生物学发生的分子机制的理解已经达到了一个关键阶段，假设和实验方法的交叉受精对于未来十年的研究重点至关重要。RNA编辑的生物学意义是会议各个方面反复出现的主题。 RNA编辑的研究者之间有许多共同的问题和实验目标，尽管编辑发生的生物体的多样性，以及被修饰的序列的明显差异。 对于理解每个编辑系统来说，重要的是对这些过程修饰的RNA底物的基本描述。 类似地，关于RNA编辑的机制、特异性、保真度和持续合成能力的普遍感兴趣的问题可以通过生物化学和分子生物学技术与体外编辑系统的开发相结合来解决。 RNA编辑调控的细胞和分子方面也在进化水平以及不同组织和发育过程中编辑活动的发生方面得到广泛研究。最后，关于其他形式的RNA加工的信息可能会对理解RNA编辑机制产生影响，反之亦然。

0091286 Ronald B. Emeson and Carlyle B. StormA Gordon Research Conference on RNA Editing is planned for January 21-26, 2001 at the Doubletree Hotel in Ventura, California. RNA editing is the co- or post-transcriptional modification of RNA which results in the insertion, deletion or substitution of nucleotides. RNA editing can therefore correct, extend or diversify the information encoded within the corresponding genomic sequence and can dramatically alter the function of the modified RNAs. For example, editing events within the mammalian central nervous system can increase the diversity of neurotransmitter receptor expression and serve to effectively modulate neuronal signaling pathways. Equally significant is the cellular regulation of many of the RNA editing processes which provides for developmental, tissue-specific and metabolic fine tuning of protein function and biochemical pathways. The understanding of molecular mechanisms underlying RNA editing and their biological occurrence has reached a critical stage where cross-fertilization of hypotheses and experimental approaches is essential for focus in the next decade of research. The biological significance of RNA editing is a recurring theme throughout all aspects of the conference. There are many common questions and experimental goals among investigators of RNA editing despite the diversity of organisms wherein editing occurs, and the apparent dissimilarities in sequences which are modified. Important to the understanding of every editing system is a basic description of the RNA substrates that are modified by these processes. Similarly, questions of general interest concerning the mechanism, specificity, fidelity and processivity of RNA editing can be addressed with a combination of biochemical and molecular biological techniques coupled with the development of in vitro editing systems. The cellular and molecular aspects of RNA editing regulation are also broadly being pursued at the level of evolution as well as the occurrence of editing activities in different tissues and during development. Finally, information about other forms of RNA processing is likely to have implications for understanding RNA editing mechanisms, and vice versa.