Gordon Research Conference on RNA Editing to be held January 21-26, 2001, in Ventura, California

[00:91286] Ronald B. Emeson和Carlyle B. StormA Gordon关于RNA编辑的研究会议计划于2001年1月21日至26日在加州文图拉的双树酒店举行。RNA编辑是RNA的共或转录后修饰，其结果是核苷酸的插入、删除或替代。因此，RNA编辑可以纠正、扩展或多样化相应基因组序列中编码的信息，并可以显著改变修饰RNA的功能。例如，哺乳动物中枢神经系统内的编辑事件可以增加神经递质受体表达的多样性，并有效调节神经元信号通路。同样重要的是许多RNA编辑过程的细胞调节，这些过程提供了蛋白质功能和生化途径的发育，组织特异性和代谢微调。对RNA编辑及其生物学发生的分子机制的理解已经达到了一个关键阶段，假设和实验方法的交叉受精是未来十年研究的重点。RNA编辑的生物学意义是贯穿会议各个方面的一个反复出现的主题。尽管发生编辑的生物体存在多样性，并且被修饰的序列存在明显的差异，但RNA编辑研究者之间存在许多共同的问题和实验目标。对每个编辑系统的重要理解是对这些过程修饰的RNA底物的基本描述。同样，关于RNA编辑的机制、特异性、保真度和处理性的普遍问题可以通过生物化学和分子生物学技术的结合以及体外编辑系统的发展来解决。RNA编辑调控的细胞和分子方面也被广泛地在进化水平上进行研究，以及在不同组织和发育过程中编辑活动的发生。最后，关于其他形式RNA加工的信息可能对理解RNA编辑机制有影响，反之亦然。

0091286 Ronald B. Emeson and Carlyle B. StormA Gordon Research Conference on RNA Editing is planned for January 21-26, 2001 at the Doubletree Hotel in Ventura, California. RNA editing is the co- or post-transcriptional modification of RNA which results in the insertion, deletion or substitution of nucleotides. RNA editing can therefore correct, extend or diversify the information encoded within the corresponding genomic sequence and can dramatically alter the function of the modified RNAs. For example, editing events within the mammalian central nervous system can increase the diversity of neurotransmitter receptor expression and serve to effectively modulate neuronal signaling pathways. Equally significant is the cellular regulation of many of the RNA editing processes which provides for developmental, tissue-specific and metabolic fine tuning of protein function and biochemical pathways. The understanding of molecular mechanisms underlying RNA editing and their biological occurrence has reached a critical stage where cross-fertilization of hypotheses and experimental approaches is essential for focus in the next decade of research. The biological significance of RNA editing is a recurring theme throughout all aspects of the conference. There are many common questions and experimental goals among investigators of RNA editing despite the diversity of organisms wherein editing occurs, and the apparent dissimilarities in sequences which are modified. Important to the understanding of every editing system is a basic description of the RNA substrates that are modified by these processes. Similarly, questions of general interest concerning the mechanism, specificity, fidelity and processivity of RNA editing can be addressed with a combination of biochemical and molecular biological techniques coupled with the development of in vitro editing systems. The cellular and molecular aspects of RNA editing regulation are also broadly being pursued at the level of evolution as well as the occurrence of editing activities in different tissues and during development. Finally, information about other forms of RNA processing is likely to have implications for understanding RNA editing mechanisms, and vice versa.