Conference: Energy Landscapes of Proteins, Glasses and Clusters: Dynamics, Folding, Function and Prediction, to be held April 1-5, 2001 in San Diego, CA

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Brooks, III Charles L.MCB-0091839Energy landscape theory was the springboard for development of the "new view'" of proteinfolding. This framework is responsible for our growing quantitative understanding ofprotein folding mechanism and detailed connections to experiments probing the foldingprocess. Parallel development of landscape theory in the study of clusters and glasses hasalso significantly shaped understanding in this field. The interchange of ideas andconcepts between these two distinct areas has added to the growth of each. However, moredetailed exchanges and forums for discussion and presentation of underlying ideas andquestions will aid continuing development of both areas. The goal of this symposium is toprovide this forum for a discussion of common themes between folding and glasses andcluster phenomena, to promote the exchange of ideas between these communities, to surveythe advances that have hallmarked each area, and to point to the challenges that remain inboth.The exciting new advances that have taken place in these areas of investigation would havebeen impossible without the integration of the new theoretical and experimental advancesin computational chemistry and physical chemistry that have been successfully applied tomolecular biology and biochemistry. In this symposium, we will integrate the differentgroups that have taken part in shaping the successes this interdisciplinary persuit aimedat a quantitative understanding of the folding problem. The ACS Spring Meeting in 2001 atSan Diego will provide the appropriate forum for this event.