Conference: Energy Landscapes of Proteins, Glasses and Clusters: Dynamics, Folding, Function and Prediction, to be held April 1-5, 2001 in San Diego, CA

能量景观理论是蛋白质折叠“新观点”发展的跳板。这个框架负责我们对蛋白质折叠机制的定量理解，并与探索折叠过程的实验详细联系。景观理论在集群和玻璃研究中的平行发展也显著地塑造了这一领域的认识。这两个不同领域之间思想和概念的交流促进了各自的发展。然而，更详细的交流和论坛，以讨论和展示潜在的想法和问题，将有助于这两个领域的持续发展。本次研讨会的目的是为讨论折叠、玻璃和聚束现象之间的共同主题提供一个论坛，促进这些社区之间的思想交流，调查每个领域的进步，并指出这两个领域仍然存在的挑战。如果没有计算化学和物理化学中已经成功应用于分子生物学和生物化学的新的理论和实验进展的整合，在这些研究领域中发生的令人兴奋的新进展是不可能的。在本次研讨会上，我们将整合参与塑造成功的不同小组，这一跨学科的追求旨在定量理解折叠问题。2001年在圣地亚哥举行的ACS春季会议将为这一活动提供适当的论坛。

Brooks, III Charles L.MCB-0091839Energy landscape theory was the springboard for development of the "new view'" of proteinfolding. This framework is responsible for our growing quantitative understanding ofprotein folding mechanism and detailed connections to experiments probing the foldingprocess. Parallel development of landscape theory in the study of clusters and glasses hasalso significantly shaped understanding in this field. The interchange of ideas andconcepts between these two distinct areas has added to the growth of each. However, moredetailed exchanges and forums for discussion and presentation of underlying ideas andquestions will aid continuing development of both areas. The goal of this symposium is toprovide this forum for a discussion of common themes between folding and glasses andcluster phenomena, to promote the exchange of ideas between these communities, to surveythe advances that have hallmarked each area, and to point to the challenges that remain inboth.The exciting new advances that have taken place in these areas of investigation would havebeen impossible without the integration of the new theoretical and experimental advancesin computational chemistry and physical chemistry that have been successfully applied tomolecular biology and biochemistry. In this symposium, we will integrate the differentgroups that have taken part in shaping the successes this interdisciplinary persuit aimedat a quantitative understanding of the folding problem. The ACS Spring Meeting in 2001 atSan Diego will provide the appropriate forum for this event.