Gaseous Ion Transport in a FAIMS Apparatus

FAIMS 装置中的气态离子传输

• 批准号: 0092436
• 负责人: Larry Viehland
• 金额: $ 10.8万
• 依托单位: Chatham College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-01 至 2004-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0092436&HistoricalAwards=false
• 关键词: Gaseous; Ion; Transport; FAIMS; Apparatus

Professor Larry Viehland of Chatham College is funded by the Theoretical and Computational Chemistry program to perform theoretical studies on a new separation method based on ion mobility spectrometry (IMS). IMS is based on measuring the average drift velocity of different ions through a neutral gas under the influence of an electrostatic field. The PI is conducting a two pronged approach to the theoretical study of a new aspect of IMS, namely the use of asymmetric applied fields (FAIMS). First, simple extensions of methods employed for similar projects involving drift tube mass spectrometers will be applied to questions about peak shape, ion transmission efficiencies and model cross sections. Undergraduates will be involved in this portion of the research. Secondly, the PI will himself develop new kinetic and dynamic calculations allowing, for example, the calculation of transport cross sections from a set of potential energy surfaces. Separation methods based on ion mobility pervade analytical chemistry, and IMS has become an important technique for the detection of chemical and biological compounds in the field due to its high sensitivity, amenability to miniaturization and ruggedness in operation. Improvements in this method are likely to be rapidly assimilated in applications such as industrial quality control and environmental sampling. This work is to be conducted with undergraduate students at Chatham College, a women's college.

查塔姆学院的Larry Viehland教授受到理论和计算化学项目的资助，对一种基于离子迁移率光谱(IMS)的新分离方法进行理论研究。IMS是基于测量不同离子在静电场影响下通过中性气体的平均漂移速度。PI正在进行双管齐下的方法来对IMS的一个新方面进行理论研究，即使用非对称应用场(FAIMS)。首先，对涉及漂移管质谱计的类似项目所采用的方法进行简单扩展，以解决峰形状、离子传输效率和模型截面等问题。本科生将参与这部分研究。其次，PI自己将开发新的动力学和动力学计算，例如，允许从一组势能面计算输运截面。基于离子迁移率的分离方法渗透到分析化学中，离子质谱仪以其灵敏度高、易于小型化和操作坚固耐用等优点，已成为分析化学和生物化合物检测的重要技术手段。这种方法的改进很可能在工业质量控制和环境采样等应用中迅速被吸收。这项工作将与查塔姆学院的本科生一起进行，查塔姆学院是一所女子学院。