CAREER: Synthesis of Allelopathic Agents as Leads to New Agrochemicals

从向日葵中分离的天然产物、向日葵醇和相关天然产物的全合成将基于仿生环氧酚环化策略进行合成。将对合成中间体和靶分子进行生物测定，以评价其作为潜在除草剂的活性。该计划的教学部分将导致开发一门新的专业药物化学课程，并在本科有机化学实验课程中引入简单的研究项目。学生们必须通过在线文献搜索来设计部分实验，从而给他们一个更“像研究”的体验。有了这个职业奖，有机合成项目支持了西华盛顿大学化学系的James R. Vyvyan教授的研究和教育活动，这是一个主要的本科机构。Vyvyan教授的研究方向是合成从向日葵中分离出来的化学物质，并评估它们抑制麻烦杂草物种生长的能力。该计划的教育部分将为有机化学实验课程开发新的研究性实验室实验，并强调讲授课程中农业和药物化学的相关性。

Total syntheses of alleopathic (compounds implicated in the chemical interaction of plants) natural products isolated from the sunflower, the heliannuols, and related natural products will be synthesized based on a biomimetic phenol-epoxide cyclization strategy. Bioassays on synthetic intermediates and target molecules will be carried out to evaluate their activity as potential herbicides. The teaching component of the plan will result in the development of a new medicinal chemistry course for majors and the introduction of simple research projects into the undergraduate organic chemistry lab course. The students must design portions of the experiments themselves by performing online literature searches thus giving them a more "research-like" experience.With this CAREER award, the Organic Synthesis Program is supporting the research and educational activities of Professor James R. Vyvyan of the Department of Chemistry at Western Washingtion University, a primarily undergraduate institution. Professor Vyvyan's research is directed towards the synthesis of chemicals isolated from the sunflower and the evaluation of their ability to inhibit the growth of troublesome weed species. The educational portion of the plan will develop new research-based laboratory experiments for the organic chemistry lab course and emphasize the relevancy of agricultural and medicinal chemistry in lecture courses.