NSF-EC Activity: Integration of New Hybrid Materials Containing Biomolecules for the Fabrication of Optical Sensor Systems

NSF-EC 活动：集成含有生物分子的新型混合材料以制造光学传感器系统

• 批准号: 0099862
• 负责人: Nasser Peyghambarian
• 金额: $ 126万
• 依托单位: University of Arizona
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0099862&HistoricalAwards=false
• 关键词: NSF; EC; Activity; Integration; New

This proposal is an interdisciplinary, collaborative, and international program between the University of Arizona Optical Sciences Center (OSC), the Department of Materials Science and Engineering at UCLA, and European-Union researchers. The program is directed at creating and developing the materials, the fabrication processes, and the components needed to demonstrate an integrated, optoelectronic system-on-a-chip capable of multifunctional sensing of chemical and biological agents. The UCLA research involves the development of sol-gel glasses doped with biomolecules that can be used as opto-chemical transducers that exploit the sensitivity and selectivity of antibodies and enzymes. The chemical and biochemical changes of the encapsulated biomolecules can be monitored by optical methods. The research will encompass the development of light sources, photodetectors, and micro-optical systems based on hybrid organic/inorganic materials. The students will receive more than simply "exposure" because they will gain hands-on experience in areas of materials synthesis, processing, spectroscopy, device fabrication and operation, as well as system integration. The interdisciplinary nature of this collaboration will also provide the students with a fundamental understanding of synthesis-property relationships for hybrid optical materials and their applications in chemical and biological sensing.This proposal is an interdisciplinary, collaborative and international program directed at creating and developing the materials, the fabrication processes, and the components needed to demonstrate an integrated, optoelectronic system-on-a-chip capable of sensing chemical and biological agents. The program consists of two components: (1) research and development of chemical and biomedical sensing materials based on the sol-gel encapsulation of biomolecules and (2) research and development of optical sensing techniques that capitalize on the optical properties of the sensing materials. The program will provide strong educational benefits to participating undergraduate and graduate student researchers and make them competitive in the world economy. The breadth of the research and our proposed international training program will ensure that the students will not only become experts in their own field of specialization, but that they also will achieve a detailed understanding of the entire sensor system. The students' knowledge will encompass the fundamental chemical and physical science and engineering of the transducer and optical system, and the realities of device fabrication. This project is being co-funded by the Mathematical and Physical Sciences Directorate (Office of Multidisciplinary Affairs, Division of Materials Research, Chemistry Division) and the Engineering Directorate (Chemical and Transport Systems Division).

该提案是亚利桑那大学光学科学中心（OSC），加州大学洛杉矶分校材料科学与工程系和欧盟研究人员之间的跨学科，合作和国际计划。该计划旨在创建和开发材料，制造工艺和所需的组件，以展示能够多功能传感化学和生物制剂的集成光电系统芯片。加州大学洛杉矶分校的研究涉及掺杂生物分子的溶胶-凝胶玻璃的开发，这些生物分子可用作利用抗体和酶的灵敏度和选择性的光化学传感器。封装的生物分子的化学和生物化学变化可以通过光学方法进行监测。该研究将包括基于混合有机/无机材料的光源，光电探测器和微光学系统的开发。学生将获得不仅仅是“曝光”，因为他们将获得材料合成，加工，光谱学，设备制造和操作以及系统集成等领域的实践经验。这项合作的跨学科性质也将为学生提供混合光学材料及其在化学和生物传感中的应用的合成-性能关系的基本理解。该提案是一个跨学科，合作和国际计划，旨在创建和开发材料，制造工艺，以及展示集成，光电子系统芯片能够感测化学和生物制剂。该计划包括两个部分：（1）基于生物分子的溶胶-凝胶封装的化学和生物医学传感材料的研究和开发，以及（2）利用传感材料的光学特性的光学传感技术的研究和开发。该计划将为参与的本科生和研究生研究人员提供强大的教育优势，使他们在世界经济中具有竞争力。研究的广度和我们提出的国际培训计划将确保学生不仅成为自己专业领域的专家，而且还将对整个传感器系统有详细的了解。学生的知识将包括传感器和光学系统的基础化学和物理科学与工程，以及设备制造的现实。该项目由数学和物理科学理事会（多学科事务办公室、材料研究司、化学司）和工程理事会（化学和运输系统司）共同资助。