GOALI: Ultrasensitive Amperometric Detection of Redox Molecules: Fundamentals and Bioanalytical Applications

该奖项授予克莱姆森大学的Stephen Creager博士，题为“氧化还原分子的超灵敏安培检测：基础和生物分析应用”，由分析和表面化学项目和多学科活动办公室支持。该项目的目标是开发一种电化学放大策略，该策略将比现有技术具有更高的灵敏度。扩增策略是基于氧化还原活性分子作为检测重要生物分子的标签。此外，还将研究一种新型的基于碳的单层涂层电极。与目前使用的电极相比，预计这些表面具有更高的稳定性。分析方面的发展将由计算机建模和模拟实验加以补充。研究的最后阶段将是将该技术应用于特定的DNA检测分析。该研究具有跨学科、挑战性和原创性，将对物理化学、生物化学、临床化学、电化学和传感器技术等领域产生潜在影响。这项研究显示了大学和工业的真正结合。在项目过程中，学生将有机会接触到工业研发，并很可能产生具有重大社会影响的产品。

The Grant Opportunities for Academic Liaison with Industry (GOALI) award to Dr. Stephen Creager of Clemson University entitled "Ultrasensitive Amperometric Detection of Redox Molecules: Fundamentals and Bioanalytical Applications" is supported by the Analytical and Surface Chemistry Program and the Office of Multidisciplinary Activities. The goal of the project is the development of an electrochemical amplification strategy which will have superior sensitivity to existing techniques. The amplification strategy is based on redox active molecules used as tags for detecting important biomolecules. Additionally studies will be performed on a new class of monolayer-coated electrodes based on carbon. These surfaces are predicted to have enhanced stability compared to electrodes currently in use. The analytical developments will be complemented by computer modeling and simulation experiments. The final stage of the research will be the application of the technique for specific DNA detection assays.The research is interdisciplinary, challenging and original, and will have potential impact on the fields of physical chemistry, biochemistry, clinical chemistry, electrochemistry and sensor technology. The research shows a true integration of University and Industry efforts. Students will get an outstanding exposure to industrial R&D during the course of the project and a product with significant societal impact could well result.