I-Corps: Rapid Ultrasensitive Biodetection Chip for Early Lung Cancer Diagnosis
I-Corps:用于早期肺癌诊断的快速超灵敏生物检测芯片
基本信息
- 批准号:2309647
- 负责人:
- 金额:$ 5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-03-15 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The broader impact/commercial potential of this I-Corps project is the development of a rapid, ultrasensitive biomarker detection chip for applications in early lung cancer diagnosis. Lung cancer is the leading cause of cancerous deaths. This cancer claimed approximately 150,000 lives in the US in 2016, accounting for 25 percent of all cancer deaths. This disease is perilous due to the difficulties in its early-stage diagnosis and poor five-year survival rate (18%). Nevertheless, if detected early, the five-year survival rate can dramatically improve to 56%. Indeed, there is a dire need to develop user-friendly and low-cost, early-stage, lung-cancer diagnosis techniques based on simple body fluids, such as blood, saliva, and urine, for integration into regular wellness checks. In meeting this demand, this project seeks to develop a robust and portable cancer biomarker detection platform for early-stage lung cancer diagnosis from simple bodily fluids.This I-Corps project is based on the development of an on-chip lung-cancer biomarker detection platform. Currently, the use of biomarker sensing is intrinsically difficult for both ultra-sensitivity and high speed in detecting biomarkers in fluidic samples. To overcome this challenge, a light-pinpointed biomolecule concentrating technology that allows for simultaneous focusing and detection of biomarkers has been developed. The proposed technology may enable high fidelity and accuracy in diagnosing lung cancer at an early stage using simple bodily fluids, such as blood and saliva, during a regular wellness check. In addition, this diagnostic method may accelerate applications of nanobiosensing in practical, early-stage cancer diagnoses.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
I-Corps项目更广泛的影响/商业潜力是开发一种用于早期肺癌诊断的快速、超灵敏的生物标志物检测芯片。肺癌是癌症死亡的主要原因。2016年,这种癌症在美国夺走了大约15万人的生命,占所有癌症死亡人数的25%。由于早期诊断困难和5年生存率低(18%),这种疾病是危险的。然而,如果及早发现,5年生存率可以显著提高到56%。事实上,迫切需要开发基于简单体液(如血液、唾液和尿液)的用户友好且低成本的早期肺癌诊断技术,以便将其整合到常规健康检查中。为了满足这一需求,本项目寻求开发一种强大的便携式癌症生物标志物检测平台,用于从简单的体液中诊断早期肺癌。这个I-Corps项目是基于芯片上肺癌生物标志物检测平台的开发。目前,生物标志物传感技术在检测流体样品中的生物标志物方面存在超灵敏度和高速度的难题。为了克服这一挑战,一种可以同时聚焦和检测生物标志物的光定位生物分子浓缩技术已经被开发出来。这项提议的技术可以在常规健康检查中使用简单的体液,如血液和唾液,在早期诊断肺癌时实现高保真度和准确性。此外,这种诊断方法可能会加速纳米生物传感在实际的早期癌症诊断中的应用。该奖项反映了美国国家科学基金会的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Donglei Emma Fan其他文献
Donglei Emma Fan的其他文献
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{{ truncateString('Donglei Emma Fan', 18)}}的其他基金
PFI (MCA): Rapid Ultrasensitive Biomarker Detection Chip for Early Lung Cancer Diagnosis
PFI (MCA):用于早期肺癌诊断的快速超灵敏生物标志物检测芯片
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2219221 - 财政年份:2022
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1930649 - 财政年份:2019
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Biosubstance Delivery and Detection Platform based on Nanoparticle Robots
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1710922 - 财政年份:2017
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$ 5万 - 项目类别:
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Innovative Processes for Fabricating Three-Dimensional Ultrathin Foams with Enhanced Thermal Properties
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1563382 - 财政年份:2016
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$ 5万 - 项目类别:
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2014 MRS Symposium H: Micro/Nano Engineering and Devices for Molecular and Cellular Manipulation, Stimulation and Analysis; Boston, Massachusetts; 30 November - 5 December 2014
2014年MRS研讨会H:用于分子和细胞操纵、刺激和分析的微/纳米工程与装置;
- 批准号:
1451060 - 财政年份:2014
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$ 5万 - 项目类别:
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EAGER: Robotized Plasmonic Nanosensors for High-Throughput Detection
EAGER:用于高通量检测的机器人化等离子体纳米传感器
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1446489 - 财政年份:2014
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$ 5万 - 项目类别:
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CAREER: Novel Mechanism for Assembling Large Arrays of Rotary Nano- Electromechanical Devices Using Nanoscale Building Blocks
职业:使用纳米级积木组装大型旋转纳米机电设备阵列的新颖机制
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1150767 - 财政年份:2012
- 资助金额:
$ 5万 - 项目类别:
Standard Grant
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