Effects of Tissue Architecture on Vascular Mechanics: Role of the Hierarchical Structure and Constituent Evolution of Elastin
组织结构对血管力学的影响:弹性蛋白的层次结构和成分进化的作用
基本信息
- 批准号:0106010
- 负责人:
- 金额:$ 24.99万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2001
- 资助国家:美国
- 起止时间:2001-09-15 至 2004-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Effects of Tissue Architecture on Vascular Mechanics:ROLE OF THE HIERARCHICAL STRUCTURE AND CONSTITUENT EVOLUTION OF ELASTINThis proposal combines the techniques and approaches of several disciplines, including mechanics, polymer physics, and molecular biology, to study the role of elastin in the arterial wall. Arteries are complex heterogenous structures with profound ability to remodel in response to biochemical and mechanical stimuli. Since arterial diseases like atherosclerosis and aneurysms directly correlate with changes in the amounts of elastin in the vessel wall, it is important to characterize the mechanical properties of arteries with varying amounts of elastin. The project aims to hierarchically link tissue microstructure and biochemical composition of arterial walls to their emergent mechanical behavior. A primary goal of this work is to study the effect of constituents on the structural properties of vessels. The mechanical tests will be used to assess the effects of a changed tissue microstructure on its overall constitutive behavior. In order to link changes in mechanical behavior with alterations in tissue microstructure, structural relationships will be characterized using biochemical methods. The results of this study have broad applicability to vascular mechanics and clinical treatments for arterial diseases.
组织结构对血管力学的影响:弹性蛋白的层次结构和成分演变的作用本研究结合了力学、高分子物理学和分子生物学等多个学科的技术和方法,来研究弹性蛋白在动脉壁中的作用。动脉是复杂的异质结构,具有响应生化和机械刺激的深刻的重塑能力。由于动脉粥样硬化和动脉瘤等动脉疾病与血管壁中弹性蛋白量的变化直接相关,因此重要的是表征具有不同量的弹性蛋白的动脉的机械性质。该项目旨在将动脉壁的组织微观结构和生化成分与其紧急机械行为分层联系起来。这项工作的主要目标是研究成分对血管结构特性的影响。力学测试将用于评估组织微观结构变化对其整体本构行为的影响。 为了将力学行为的变化与组织微观结构的改变联系起来,将使用生物化学方法表征结构关系。本研究结果对血管力学和动脉疾病的临床治疗具有广泛的适用性。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Lisa Pruitt其他文献
Factors Associated With Early Discharge in Pediatric Trauma Patients Transported by Rotor: A Retrospective Analysis.
与转子转运的小儿创伤患者早期出院相关的因素:回顾性分析。
- DOI:
10.1016/j.amj.2023.09.010 - 发表时间:
2023 - 期刊:
- 影响因子:0
- 作者:
Derek R. Marlor;David Juang;Lisa Pruitt;Nelimar Cruz;Shai Stewart;Jack Senna;Jennifer Flint - 通讯作者:
Jennifer Flint
Abiraterone acetate plus prednisone in non-metastatic biochemically recurrent castration-naïve prostate cancer.
醋酸阿比特龙加泼尼松治疗非转移性生化复发去势前列腺癌。
- DOI:
- 发表时间:
2021 - 期刊:
- 影响因子:8.4
- 作者:
N. Spetsieris;M. Boukovala;I. Alafis;John B. Davis;A. Zurita;Xuemei Wang;S. Tu;B. Chapin;A. Aparicio;P. Corn;J. Wang;S. Subudhi;J. Araujo;J. Papadopoulos;Lisa Pruitt;J. Weldon;C. Logothetis;E. Efstathiou - 通讯作者:
E. Efstathiou
Erratum: “Nanoindentation of polydimethylsiloxane elastomers: Effect of crosslinking, work of adhesion,and fluid environment on elastic modulus” [J. Mater.Res. 20, 2820 (2005)]
- DOI:
10.1557/jmr.2005.0354e - 发表时间:
2006-02-01 - 期刊:
- 影响因子:2.900
- 作者:
Fernando Carrillo;Shikha Gupta;Mehdi Balooch;Sally J. Marshall;Grayson W. Marshall;Lisa Pruitt;Christian M. Puttlitz - 通讯作者:
Christian M. Puttlitz
Lisa Pruitt的其他文献
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{{ truncateString('Lisa Pruitt', 18)}}的其他基金
Nano and Microscale Mechanisms of Fatigue, Fracture and Wear in Polyethylene
聚乙烯疲劳、断裂和磨损的纳米和微观机制
- 批准号:
0505272 - 财政年份:2005
- 资助金额:
$ 24.99万 - 项目类别:
Standard Grant
Individual Nomination for Professor Lisa Pruitt PAESMEM
Lisa Pruitt PAESMEM 教授个人提名
- 批准号:
0328623 - 财政年份:2004
- 资助金额:
$ 24.99万 - 项目类别:
Standard Grant
MRI: Instrumentation Acquisition for the Development of a Wet Facility for Nano-Bioengineering
MRI:用于纳米生物工程湿设施开发的仪器采购
- 批准号:
0079243 - 财政年份:2000
- 资助金额:
$ 24.99万 - 项目类别:
Standard Grant
CAREER: Long Term Performance Issues in Advanced Polymers: Understanding the Evolution of Structure-Property Relationships
职业:先进聚合物的长期性能问题:了解结构-性能关系的演变
- 批准号:
9624978 - 财政年份:1996
- 资助金额:
$ 24.99万 - 项目类别:
Standard Grant
The Effect of Environment on The Fatigue and Fracture Response of Advanced Polymers and Composites
环境对先进聚合物和复合材料疲劳和断裂响应的影响
- 批准号:
9410979 - 财政年份:1994
- 资助金额:
$ 24.99万 - 项目类别:
Standard Grant
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