SBIR Phase I: Automated Analyzer for Drug Delivery Systems

SBIR 第一阶段：药物输送系统自动分析仪

• 批准号: 0109691
• 负责人: Douglas Worsnop
• 金额: $ 10万
• 依托单位: Aerodyne Research Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2001-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0109691&HistoricalAwards=false
• 关键词: SBIR; Phase; Automated; Analyzer; Drug

This Small Business Innovation Research Phase I (SBIR) project will develop a new class of real time aerosol mass spectrometers (AMSs) for analysis of respirable powder and liquid aerosol in pulmonary drug delivery systems. Three parameters control the effective delivery of drugs to the lungs: (1) the number density of entrained aerosol particles per unit volume of respirable fluid; (2) the particle size distribution; (3) the concentrations of active ingredients as a function of particle size. Aerosol Mass Spectrometers, with proper calibration, can measure all three parameters simultaneously. Aerodyne Research, Inc. (ARI), in collaboration with several university research groups, has developed, demonstrated, and commercialized an innovative and quantitative AMS system. With suitable modification and calibration, this system could greatly reduce the time and effort required to characterize pulmonary drug delivery systems, both for research and for production quality assurance. This Phase I project will design and test a real-time AMS system to characterize novel pulmonary drug delivery systems.The principal commercial application of this project will be in the pulmonary drug delivery analyzer market. Potential customers are likely to include drug delivery companies, pharmaceutical companies, academic research organizations and regulatory agencies.

这个小型企业创新研究第一阶段(SBIR)项目将开发一类新的实时气溶胶质谱仪(AMSS)，用于分析肺部给药系统中的可呼吸粉末和液体气溶胶。有三个参数控制药物向肺部的有效输送：(1)每单位体积呼吸液中携带的气雾剂颗粒的数量密度；(2)颗粒大小分布；(3)有效成分浓度与颗粒大小的函数关系。经过适当的校准，气溶胶质谱仪可以同时测量这三个参数。Aerodyne Research，Inc.(ARI)与几个大学研究小组合作，开发、演示了一种创新的定量AMS系统，并将其商业化。通过适当的修改和校准，该系统可以极大地减少用于研究和生产质量保证的肺部给药系统的表征所需的时间和精力。这个第一阶段的项目将设计和测试一个实时AMS系统，以表征新的肺部药物输送系统。该项目的主要商业应用将是在肺部药物输送分析器市场。潜在客户可能包括药品递送公司、制药公司、学术研究组织和监管机构。