Hyperacuity in the Auditory System
听觉系统的超敏锐度
基本信息
- 批准号:0109872
- 负责人:
- 金额:$ 38.25万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2001
- 资助国家:美国
- 起止时间:2001-08-15 至 2007-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Reed0109872 Certain cells in the mammalian auditory brainstem (threeneurons from the periphery) show exceptionally small standarddeviations in the microsecond range of the timing of the firstaction potential response under repeated trials of the samesound. Moreover, the latency and its standard deviation arequite independent of frequency and decibel level over largeranges. This behavior is exceptional since the inputs to thesecells come from octopus and other cells in the contralateralcochlear nucleus, a nucleus which is ennervated by auditory nervefibers that have much larger standard deviations and highdependence on frequency and decibel level. Thus, this system isan example of how the brain can use relatively sloppy andvariable devices (neurons) to perform surprisingly accuratecalculations. Professor Michael Reed, with colleague physiologistJoseph Blum, investigates this system with three researchprojects: (i) They create and investigate by machine computationa large scale mathematical model of the whole system using knownphysiological properties of auditory nerve fibers and recentlydiscovered properties of octopus cells; (ii) They usemathematical analysis investigate of the improvement of thestandard deviation of latency in converging networks where thetarget cells require coincident inputs within time windows inorder to fire; (iii) They use partial differential equations tounderstand the special properties of dendritic informationprocessing in octopus cells. Using mathematics and machine computation, Professor MichaelReed continues to study how groups of cells (neurons) in theauditory brainstem perform calculations that individual cells cannot do by themselves. Neurons are inherently sloppy and variabledevices that perform differently even under (apparently) the sameconditions with the same inputs. Nevertheless, large groups ofthese neurons are able to perform together, reliably, highlyaccurate calculations. This project tries to understand thisapparent paradox. The project sheds light on how and why humanbrains are organized the way they are and it suggests newmechanisms for the development of man-made thinking devices.
Reed0109872 哺乳动物听性脑干中的某些细胞(从外围算起的三个神经元)在相同声音的重复试验下,第一个动作电位反应的时间在微秒范围内显示出非常小的标准偏差。 在较大范围内,潜伏期及其标准差与频率和分贝无关。 这种行为是特殊的,因为这些细胞的输入来自章鱼和对侧皮质核的其他细胞,该核由听觉神经纤维支配,具有更大的标准偏差和对频率和分贝水平的高度依赖性。 因此,这个系统是一个例子,说明大脑如何使用相对松散和可变的设备(神经元)来执行令人惊讶的精确计算。 Michael Reed教授和他的同事、生理学家Joseph Blum通过三个研究项目对这个系统进行了研究:(i)他们利用已知的听觉神经纤维的生理特性和最近发现的章鱼细胞的特性,通过机器计算建立并研究了整个系统的大规模数学模型;(二)他们使用数学分析研究了在目标细胞需要重合的融合网络中延迟标准差的改善。在时间窗口内的输入,以便消防;(iii)他们使用偏微分方程tunderstand章鱼细胞树突信息处理的特殊属性。 利用数学和机器计算,MichaelReed教授继续研究听觉脑干中的细胞(神经元)群如何执行单个细胞无法自己完成的计算。 神经元本质上是一种松散而多变的装置,即使在(显然)相同的条件下,输入相同,表现也不同。 然而,大量的神经元能够一起进行可靠的、高度精确的计算。 这个项目试图理解这个明显的悖论。 该项目揭示了人类大脑是如何以及为什么以这种方式组织的,并为人造思维装置的发展提出了新的机制。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Michael Reed其他文献
Persistent Fetal Gene Expression Patterns During Assist Device Support
辅助设备支持期间持续的胎儿基因表达模式
- DOI:
- 发表时间:
2009 - 期刊:
- 影响因子:0
- 作者:
B. Lowes;R. Zolty;S. Shakar;A. Brieke;Norman;Gray;Michael Reed;M. Calalb;W. Minobe;J. Lindenfeld;E. Wolfel;M. Geraci;M. Bristow;J. Cleveland - 通讯作者:
J. Cleveland
A Novel Intervention to Reduce Bronchoscopy Laboratory Costs
- DOI:
10.1378/chest.1993730 - 发表时间:
2014-10-01 - 期刊:
- 影响因子:
- 作者:
Kevin Kane;Christopher Gilbert;Jennifer Toth;Michael Reed - 通讯作者:
Michael Reed
Rationale for the Implementation of Low-Volume, High-Intensity Exercise in School Physical Education
学校体育实施小量高强度运动的理由
- DOI:
- 发表时间:
2017 - 期刊:
- 影响因子:0
- 作者:
Michael Reed;Kay Daigle - 通讯作者:
Kay Daigle
Endobronchial Valves as Destination Therapy for Secondary Spontaneous Pneumothorax in a Man With Acute Myelogenous Leukemia
- DOI:
10.1378/chest.1701367 - 发表时间:
2013-10-01 - 期刊:
- 影响因子:
- 作者:
Umar Osman;Jennifer Toth;Christopher Gilbert;Michael Reed - 通讯作者:
Michael Reed
A Case of Pulmonary Alveolar Microlithiasis Presenting as Crazy Paving
- DOI:
10.1378/chest.1989412 - 发表时间:
2014-10-01 - 期刊:
- 影响因子:
- 作者:
Umar Osman;Jennifer Toth;Christopher Gilbert;Michael Reed - 通讯作者:
Michael Reed
Michael Reed的其他文献
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{{ truncateString('Michael Reed', 18)}}的其他基金
Proposal Writing Workshop for Psychology Education Research and Development
心理学教育研究与发展提案写作研讨会
- 批准号:
2228188 - 财政年份:2022
- 资助金额:
$ 38.25万 - 项目类别:
Standard Grant
RUI: Asteroseismology of subdwarf B stars as representatives of high-temperature physics and horizontal branch stellar cores.
RUI:作为高温物理和水平分支恒星核心代表的亚矮B星的星震学。
- 批准号:
1312869 - 财政年份:2013
- 资助金额:
$ 38.25万 - 项目类别:
Continuing Grant
RUI: Asteroseismology of pulsating Subdwarf B stars via observational mode identification and modeling
RUI:通过观测模式识别和建模研究脉动亚矮星 B 星的星震学
- 批准号:
1009436 - 财政年份:2010
- 资助金额:
$ 38.25万 - 项目类别:
Continuing Grant
EMSW21-RTG: Enhanced Training and Recruitment in Mathematical Biology
EMSW21-RTG:数学生物学加强培训和招聘
- 批准号:
0943760 - 财政年份:2010
- 资助金额:
$ 38.25万 - 项目类别:
Continuing Grant
RUI: The Baker Observatory Sub-minute Survey: Exploring the galaxy at high temporal resolution.
RUI:贝克天文台亚分钟巡天:以高时间分辨率探索星系。
- 批准号:
0913175 - 财政年份:2009
- 资助金额:
$ 38.25万 - 项目类别:
Standard Grant
Analysis of Mechanisms of Biochemical Homeostasis
生化稳态机制分析
- 批准号:
0616710 - 财政年份:2006
- 资助金额:
$ 38.25万 - 项目类别:
Standard Grant
NER/SNB: Electronic Devices from Viral and Cytoskeletal Templates
NER/SNB:来自病毒和细胞骨架模板的电子设备
- 批准号:
0508338 - 财政年份:2005
- 资助金额:
$ 38.25万 - 项目类别:
Standard Grant
NIRT: Science and Technology of Nanoporous Metal Films
NIRT:纳米多孔金属薄膜科学与技术
- 批准号:
0507023 - 财政年份:2005
- 资助金额:
$ 38.25万 - 项目类别:
Standard Grant
Understanding subdwarf B stars through asteroseismology
通过星震学了解亚矮星 B 星
- 批准号:
0307480 - 财政年份:2003
- 资助金额:
$ 38.25万 - 项目类别:
Standard Grant
Mathematical Investigation of Neural Processing in the Auditory Brainstem
听觉脑干神经处理的数学研究
- 批准号:
9805761 - 财政年份:1998
- 资助金额:
$ 38.25万 - 项目类别:
Standard Grant
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