Comparative Genomics of Angiosperm MADS-Box Genes

被子植物 MADS-Box 基因的比较基因组学

• 批准号: 0110115
• 负责人: Vivian Irish
• 金额: $ 43.54万
• 依托单位: Yale University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2004-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0110115&HistoricalAwards=false
• 关键词: Comparative; Genomics; Angiosperm; MADS; Box

Plant MADS-box genes encode transcriptional regulators that are required for a variety of critical developmental processes, including organ identity, flowering, fruit development, root development, and pattern formation. This family of genes has diversified dramatically during the evolution of vascular plants, and especially within the angiosperms, resulting in the large number of these genes in modern flowering plant species. The problem at hand is to define the roles of these MADS-box genes, as well as to understand the evolutionary changes that resulted in their great diversity of functions. Cloning and sequencing MADS-box genes in a variety of plant species will lay the groundwork to address this question. These sequences will be used in a series of phylogenetic analyses to determine the relationships among these genes. Understanding the diversity of functions encoded by the MADS-box genes, coupled with knowledge of how these processes have been modified through the evolution of vascular plants, will be key in developing targeted strategies for manipulating the growth and development of non-model plant species.

植物MADS盒基因编码的转录调节因子是多种关键发育过程所必需的，包括器官的身份，开花，果实发育，根的发育和图案的形成。在维管植物的进化过程中，特别是在被子植物中，这个基因家族发生了巨大的变化，导致现代开花植物物种中大量存在这些基因。目前的问题是确定这些MADS盒基因的作用，以及了解导致其功能多样性的进化变化。克隆和测序各种植物物种中的MADS盒基因将为解决这一问题奠定基础。这些序列将用于一系列系统发育分析，以确定这些基因之间的关系。了解MADS盒基因编码的功能的多样性，再加上这些过程是如何通过维管植物的进化进行修改的知识，将是制定有针对性的策略来操纵非模式植物物种的生长和发育的关键。