The Development of a Prokaryotic Annotation Engine

TIGR基因组研究所开发了注释工具和复杂的网络显示，以便向科学界展示这些信息。注释系统包括一个软件，允许其注释人员发起细菌注释项目，通过手动管理更新数据，并在TIGR的网站和GenBank上以电子方式发布这些数据。TIGR Web Display包括一个数据库系统，能够表示所有完整的微生物基因组、图形显示，并允许用户对这些数据执行复杂的特殊查询。上述工具完全是为在TIGR本地或在TIGR Web服务器上运行软件而设计的。目前的项目将为开发软件提供资源，科学家将使用这些软件在他们自己的机器上本地运行这些软件。这将允许用户轻松访问与TIGR制定的一套完善的标准操作程序一致的注释系统，并将有助于确保许多测序中心的注释的一致性。通过将在TIGR开发的软件交给用户，他们还将能够修改和改进表示系统，并使用图形显示来促进对细菌基因组信息的个体分析。

The Institute for Genomic Research, TIGR, has developed tools for annotation and a complex web display forpresenting this information to the scientific community. The annotation system includes software that allows its annotation staff to initate a bacterial annotation project, update that data with manual curation, andto electronically publish that data on TIGR's web site and at GenBank. TIGR web display includes a database system with the capability of representing all completed microbial genomes, graphical displays, andthe ability to allow users to perform complex ad hoc queries on that data.The above tools were designed strictly for the purpose of running thosesoftware locally at TIGR or on TIGR web servers. The current project will provide resources for the development of software that will be used by scientists to run those software locally on their own machines. This will allow users easy access to annotation systems that are consistent with the well-developed set of standard operational procedures developed at TIGR and will help ensure consistency of annotation across manysequencing centers. By placing the software developed at TIGR in the hands of users, they will also be able to modify and improve upon the representation system, and use the graphical display to promoteindividual analysis of bacterial genome information.