Molecular Genetics of Cell Differentiation in the Arabidopsis Shoot Epidermis

拟南芥芽表皮细胞分化的分子遗传学

• 批准号: 0110418
• 负责人: John Larkin
• 金额: $ 33万
• 依托单位: Louisiana State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2005-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0110418&HistoricalAwards=false
• 关键词: Molecular; Genetics; Cell; Differentiation; Arabidopsis

0110418LarkinThe process of cell differentiation is the process by which cells become specialized during the development of multicellular organisms. Although a great deal is known about how cell differentiation is initiated, considerably less is known about how these early events control the actual events leading to cellular specialization. The shoot epidermal hairs (trichomes) of Arabidopsis are now well established as a model for the study of plant cell differentiation. The long-term goal of this research program is to uncover the molecular mechanisms connecting the trichome cell fate decision to the generation of the mature trichome phenotype. There is particular interest in the endoreduplication cell cycle during trichome development. The specific goals of the proposed research are to identify direct downstream targets of the trichome initation regulators GL3 and GL1, to isolate the SIM gene and determine its function in the endoreduplication cell cycle, and to isolate extragenic modifiers of sim mutants.

0110418拉金细胞分化过程是多细胞生物体发育过程中细胞特化的过程。 虽然我们对细胞分化是如何开始的已经有了很多了解，但对这些早期事件如何控制导致细胞特化的实际事件却知之甚少。 拟南芥的茎表皮毛（毛状体）现在被很好地建立为研究植物细胞分化的模型。 本研究计划的长期目标是揭示毛状体细胞命运决定与成熟毛状体表型产生之间的分子机制。 毛状体发育过程中的核内复制细胞周期特别令人感兴趣。 拟议的研究的具体目标是确定直接下游目标的毛状体起始调节剂GL3和GL1，分离SIM基因，并确定其功能的核内复制细胞周期，并分离基因外修饰SIM突变体。