Probing Metalloenzymes with Sensitizer-Linked Substrates

美国国家科学基金会化学部的无机、生物无机和有机金属化学项目支持加州理工学院贝克曼研究所的Harry Gray博士（PI）和John Richards博士（co-PI）的研究工作，以开发和应用创新的“复合物内”电子转移反应来检测氧化还原金属酶的反应途径，金属酶是一系列具有重要生物学相关性的蛋白质。有了这一支持，对金属酶的化学性质将有新的认识。拟议的基础研究的结果将大大增加知识库，这些知识库将跨越几个学科，并将对生物和生化领域产生重大影响。学生和博士后同事将获得各种实验技术的宝贵经验，并学习跨学科方法的见解。

The Inorganic, Bioinorganic and Organometallic Chemistry Program of the Division of Chemistry, National Science Foundation, supports the research work of Dr. Harry Gray (PI) and Dr. John Richards (co-PI) of the Beckman Institute at Caltech to develop and apply innovative "intra-complex" electron transfer reactions to examine reaction pathways of redox metalloenzymes, a host of proteins that have significant biological relevance. With this support, a new understanding of the chemistry of metalloenzymes will be forthcoming. The results from the proposed fundamental study will significantly add to the knowledge base that will cut across several disciplines, and will impact markedly into biological and biochemical fields. Students and post-doctoral associates will gain invaluable experience in a variety of experimental techniques and learn insights into interdisciplinary methodologies.