Methods for Analyzing Lethal Gases of Endophytes

内生菌致命气体的分析方法

• 批准号: 0114469
• 负责人: Gary Strobel
• 金额: $ 5.6万
• 依托单位: Montana State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-15 至 2002-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0114469&HistoricalAwards=false
• 关键词: Methods; Analyzing; Lethal; Gases; Endophytes

In this Small Grant for Exploratory Research (SGER) supported by the Organic and Macromolecular Chemistry Program, Professor Gary A. Strobel of the Department of Plant Sciences at Montana State University, will trap, isolate and characterize the volatile substances produced by Muscodor alba, a new fungal genus and species isolated from the Honoduran rainforest. It has been demonstrated that at least one of the gaseous compounds produced by M. alba is lethal to virtually all other endophytic fungi and bacteria that are present in the stem tissues of its plant host. The separation and identification of the volatile components possessing antimicrobial activity will be pursued.With the support of the Organic and Macromolecular Chemistry Program, Professor Gary A. Strobel, of the Department of Plant Sciencs at Montana State University, will isolate and identify volatile organic compounds produced by a new fungal species, M. alba. This mixture of gaseous substances has been shown to be lethal to a range of other fungi and bacteria. Isolation of the bioactive product(s) may result in the identification of compounds with potential pharmaceutical applications, including antimicrobial agents.

在这个由有机和高分子化学项目支持的探索性研究小额资助计划中，加里教授A。蒙大拿州州立大学植物科学系的Strobel将捕获、分离和表征从火诺杜兰热带雨林中分离出的一种新真菌属和物种--白麝香草产生的挥发性物质。 已经证明，M. alba对存在于其植物宿主的茎组织中的几乎所有其它内生真菌和细菌都是致命的。 在有机与高分子化学项目的支持下，加里A.蒙大拿州立大学植物科学系的Strobel将分离并鉴定一种新真菌M.阿尔巴。 这种气体物质的混合物已被证明对一系列其他真菌和细菌是致命的。 生物活性产物的分离可导致鉴定具有潜在药物应用的化合物，包括抗微生物剂。