ITR/SY+PE+IM+AP COLLABORATIVE RESEARCH: Computer-linked Auto-Fabricated Models for Education in Molecular Biology

这是一项研究计划，旨在设计和实施结构分子生物学教育用途的新型人机界面。本项目将探索、定义和评估计算机生成的物理模型在教学科学内容和概念中的作用。其目的是加强对生命分子机制复杂世界的理解和交流。利用生物分子及其复合物的结构数据，参与者将通过自动化设计和制造技术建立新的物理模型原型，并开发更广泛分布的复制过程。这些模型将直接用于增强可视化和作为输入/输出设备，与交换和计算机图形交互集成，用于信息检索、操作和模拟。该项目将提供新的、切实的模式，与基因组学、蛋白质组学和其他结构分子生物学领域快速发展的基本概念和复杂数据进行互动和理解。它将使广泛的学生能够学习、查询和探索一个日益重要的科学和社会领域——生命的分子基础。物理模型将为形状在生物功能中的重要性提供触觉和视觉支持。使用物理模型作为有形的计算机界面将彻底改变学生探索和理解生物分子结构、相互作用和功能的方式。

This is a research project in the design and implementation of novel Human Computer Interfaces for educational use in structural molecular biology. This project will explore, define, and assess the role of computer-generated physical models in teaching scientific content and concepts. The purpose is to enhance the understanding and communication of the complex world of life's molecular machinery to a broad community. Using structural data on biological molecules and their complexes, the participants will prototype novel physical models via automated design and fabrication technologies and develop replication processes for broader distribution. The models will be used directly for enhance visualization and as input/output devices that interactively integrate with commutation and computer graphics for information retrieval, manipulation, and simulation.This project will provide new, tangible modes of interacting with, and understanding of, both the fundamental concepts and the complex data that are coming from the rapid advances in genomics, proteomics, and other areas of structural molecular biology. It will enable a broad range of students to learn, query, and explore in a field of growing scientific and social importance - the molecular basis of life. Physical models will give both haptic and visual support of the importance of shape in biological function. Use of physical models as tangible computer interfaces will revolutionize how students explore and understand biomolecular structure, interaction, and function.