Biological Information Technology Systems - BITS: Information Processing in Designed Neuronal Circuits

生物信息技术系统 - BITS：设计的神经元电路中的信息处理

• 批准号: 0130828
• 负责人: Bruce Wheeler
• 金额: $ 115.6万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-01 至 2006-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0130828&HistoricalAwards=false
• 关键词: Biological; Information; Technology; Systems; BITS

EIA-0130828 -Bruce C. Wheeler-University of Illinois-BITS: Information processing in Designed Neuronal CircuitsBITS: Information processing in Designed Neuronal CircuitsThe aim of this project is to enhance our understanding of information processing by small numbers of neurons arranged in designed circuits. This is an ideal time for this initiative because: We can intentionally design neuronal microcircuits due to progress in serum free media to support relatively pure neuronal populations, in microlithgraphy as applied to the deposition of proteins and other biomolecules to surfaces, and in understanding of the conditions under which sparse pattern populations of neurons become functionally active in culture.We can study the information processing capabilities of these neuronal circuits due to advances microelectrode array technology, permitting both stimulation and recording of electrical activity, as well as the supporting real-time data acquisition technology. We can analyze the data utilizing theories of neural coding derived as applications of rich theoretical foundations in signal processing and communications theory.We have three specific goals, creation of reliable, repeatable, robust neuronal circuits of cultured hippocampal neurons. Stable circuit behavior is essential to further investigation of information processing.The first aim emphasizes geometric properties, including guiding axonal extension, the second aim emphasizes functional properties, and the third aim is neuronal information processing. Models to be evaluated include rate codes, precise timing codes and phase synchronization codes.

EIA-0130828 -布鲁斯C. Wheeler-University of Illinois-BITS：Information processing in Designed Neuronal CircuitsBITS：Information processing in Designed Neuronal CircuitsThe aim of this project is to enhance our understanding of information processing by small number of neurons arranged in designed circuits. 这是一个理想的时机，因为：我们可以有意地设计神经元微电路，这是由于在无血清培养基中的进展，以支持相对纯的神经元群体，在应用于蛋白质和其他生物分子沉积到表面的显微光刻中，以及了解稀疏模式的神经元群体在培养中变得功能活跃的条件。我们可以研究神经元的信息处理能力。这些神经元回路由于先进的微电极阵列技术，允许刺激和记录电活动，以及支持实时数据采集技术。我们可以利用神经编码理论来分析数据，这些理论是在信号处理和通信理论中丰富的理论基础的应用。我们有三个具体的目标，建立可靠的、可重复的、鲁棒的培养海马神经元神经元回路。 稳定的回路行为是进一步研究信息处理的基础，第一个目标强调几何特性，包括引导轴突延伸，第二个目标强调功能特性，第三个目标是神经元信息处理。 待评估的模型包括速率码、精确定时码和相位同步码。