U.S.-Korea Cooperative Research: Micropatterned Neural Networks and Microelectrode Arrays

美韩合作研究：微图案神经网络和微电极阵列

• 批准号: 9816376
• 负责人: Bruce Wheeler
• 金额: $ 1.65万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-07-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9816376&HistoricalAwards=false
• 关键词: U.S.; Korea; Cooperative; Research; Micropatterned

9816376WheelerThis award provides funds to permit Dr. Bruce C. Wheeler, Department of Electrical and Computer Engineering, University of Illinois at Urbana-Chamoaign, to pursue with Dr. Sung June Kim, School of Electrical Engineering, Seoul National University, for 24 months, a program of cooperative research on micropatterned neural networks and microelectrode arrays. In this project, the neuronal cell patterning expertise at the University of Illinois is coupled with the microelectronics fabrication expertise at Seoul National University. The research team at the University of Illinois has shown that novel surface treatment can be used to grow micropatterned neural networks in culture. Essential elements of the technology are the ability to retard cell attachment and growth from background areas, to confine somata to desired positions, and to control axonal extension so as to create an oriented network. Microlithographic techniques, primarily microcontact printing, will be used to create patterns of biomolecules on planar culture surfaces in order to effect control of position of attachment and extension of neurons and glia. The Korean team will greatly enhance the Illinois efforts by making passive electrode arrays available on a routine basis and pursuing novel fabrication technologies for electrode design. In addition the Korean team will design and fabricate arrays incorporating active electronics for stimulation, amplification, and multiplexing. Their instrumentation goal is to obtain better signal to noise ratio by placing first stage amplifiers nearly in contact with the low level signal source. The Korean team has substantial capabilities for microelectronic fabrication and already has made devices for neural signal amplification. Collaboration on this project will provide a biological context in which to improve their designs, for the benefit of both teams.The complementary expertise of the two research teams will be mutually beneficial and will advance knowledge in this important field of research. The collaborators are highly regarded scientists in their respective fields of research. Korean and American graduate students will be included in the teams of collaborators. This project is relevant to the objectives of the U.S.-Korea Cooperative Science Program which seeks to increase the level of cooperation between U.S. and Korean scientists and engineers through the exchange of scientific information, ideas, skills, and techniques and through collaboration on problems of mutual benefit. Korean participation is supported by the Korea Science and Engineering Foundation (KOSEF).***

9816376惠勒该奖项提供资金，允许博士布鲁斯C。惠勒，电气和计算机工程系，伊利诺伊大学厄巴纳-香槟分校，继续与博士成六金，电气工程学院，首尔国立大学，为期24个月，一个项目的合作研究微图案神经网络和微电极阵列。 在该项目中，伊利诺伊大学的神经元细胞图案专业知识与首尔国立大学的微电子制造专业知识相结合。 伊利诺伊大学的研究小组已经表明，新的表面处理可以用于在培养中生长微图案神经网络。 该技术的基本要素是延迟细胞从背景区域附着和生长的能力，将胞体限制在期望的位置，以及控制轴突延伸以产生定向网络的能力。 微光刻技术，主要是微接触印刷，将被用来创建平面培养表面上的生物分子的图案，以实现控制的位置的连接和神经元和神经胶质细胞的扩展。 韩国团队将通过常规制造无源电极阵列和追求电极设计的新型制造技术，大大加强伊利诺伊州的努力。 此外，韩国团队将设计和制造包含用于刺激、放大和多路复用的有源电子器件的阵列。 他们的仪器目标是通过将第一级放大器放置在几乎与低电平信号源接触的位置来获得更好的信噪比。 韩国团队拥有强大的微电子制造能力，已经制造出神经信号放大设备。 在这个项目上的合作将提供一个生物学的背景下，以改善他们的设计，为两个团队的利益。两个研究团队的互补专业知识将是互惠互利的，并将在这一重要的研究领域推进知识。 合作者都是在各自研究领域备受推崇的科学家。 韩国和美国的研究生将被纳入合作者团队。 该项目与美国的目标有关-韩国合作科学计划，旨在通过科学信息，思想，技能和技术的交流以及通过互利问题的合作来提高美国和韩国科学家和工程师之间的合作水平。 韩国的参与得到了韩国科学和工程基金会的支持。