PECASE: Acculturation, Health, and the Ecology of Immune Function: Integrated Research and Education in Human Population Biology
PECASE:文化适应、健康和免疫功能生态学:人类群体生物学的综合研究和教育
基本信息
- 批准号:0134225
- 负责人:
- 金额:$ 30万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2002
- 资助国家:美国
- 起止时间:2002-08-15 至 2007-10-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Proposal Title: PECASE: Acculturation, health, and the ecology of immune function: Integrated research and education in human population biologyInstitution: Northwestern UniversityAcculturation and urbanization have been linked to a wide range of human health issues, but the associations are mixed: A number of studies highlight the health benefits of improved access to infrastructure, health services, and education, while others draw attention to rising rates of stress-related, chronic degenerative, and atopic diseases. Further research in this area is needed, especially since indigenous groups around the world are becoming increasingly incorporated into a single global economy. Previous research has focused largely on adults, and additional research is needed on the specific health issues confronting children and adolescents, and their unique experiences in the context of rapid culture change. In addition, improvements in the methods used to assess health and human biology are required to overcome the constraints of research conducted in field settings. This project addresses these issues in pursuit of the following objectives: 1) investigate immune function and child/adolescent health in the context of social and economic transitions in lowland Bolivia, 2) develop and evaluate minimally-invasive methods for assessing immunocompetence in remote field settings, and 3) create a series of educational opportunities in which high school, undergraduate, graduate, and international students can participate in mentored original research.Initial research efforts (Project 1) will be focused on a prospective study of culture change and health in lowland Bolivia. 600 participants between the ages of 5 and 20 years will be recruited from 9 villages, and sociocultural, demographic, socioeconomic, anthropometric, and morbidity data will be collected at multiple time points. Saliva and finger prick blood samples will be collected to assess physiological markers of immune function and health. By applying a uniform set of biological and socio-cultural methods across a range of cultural-ecological settings, this project will investigate the multidimensional nature of acculturation, and its positive and negative implications for child and adolescent well-being. In addition, assessment of immunocompetence-using methods that do not require venipuncture-in conjunction with growth and morbidity will reveal underlying physiological processes that may mediate the associations between shifting cultural-ecological environments and adverse growth and health outcomes. Subsequent research efforts (Projects 2 and 3) will be dedicated to a comparative analysis of immune development: Multiple dimensions of immunity will be compared in samples collected from 5-20 year-olds in Bolivia, Samoa, and the U.S. to gain insight into the range of variation in immune development, and to explore the contribution of a comparative, ecological perspective to current understandings of human immune function.Broader merits of the project include a number of educational initiatives: 1) development of a two-course sequence in Human Biology Research; 2) mentored research experience for undergraduate students; 3) summer workshop in laboratory methods for graduate students; 4) training of international students in Bolivia, and 5) establishment of a partnership with a local high school to provide internship and research opportunities for high school students. Participating students will engage in the scientific process, apply new methodological skills to issues in human biology and health, and become members of a collaborative research community.This project was originally funded as a CAREER award, and was converted to a Presidential Early Career Award for Engineers and Scientists (PECASE) award in May 2004.
项目名称:PECASE:文化适应、健康和免疫功能生态学:人口生物学的综合研究和教育机构:西北大学文化适应和城市化与广泛的人类健康问题有关,但两者之间的联系是复杂的:一些研究强调了改善获得基础设施、卫生服务和教育的机会对健康的好处,而另一些研究则提请注意与压力有关的慢性退行性疾病和特应性疾病的发病率不断上升。需要在这方面进行进一步的研究,特别是因为世界各地的土著群体正日益融入单一的全球经济。过去的研究主要集中于成人,需要进一步研究儿童和青少年面临的具体健康问题,以及他们在文化迅速变化背景下的独特经历。此外,需要改进用于评估健康和人类生物学的方法,以克服在实地环境中进行研究的限制。本项目旨在解决这些问题,以实现以下目标:1)调查玻利维亚低地社会和经济转型背景下的免疫功能和儿童/青少年健康;2)开发和评估用于评估偏远地区免疫能力的微创方法;3)创造一系列教育机会,使高中生、本科生、研究生和国际学生能够参与指导的原创性研究。最初的研究工作(项目1)将侧重于玻利维亚低地文化变化与健康的前瞻性研究。将从9个村庄招募600名年龄在5至20岁之间的参与者,并将在多个时间点收集社会文化、人口、社会经济、人体测量学和发病率数据。唾液和手指刺血样本将被收集,以评估免疫功能和健康的生理指标。通过在一系列文化生态环境中应用一套统一的生物学和社会文化方法,该项目将调查文化适应的多维性质,以及它对儿童和青少年福祉的积极和消极影响。此外,免疫能力评估(使用不需要静脉穿刺的方法)与生长和发病相结合,将揭示潜在的生理过程,这些生理过程可能介导不断变化的文化生态环境与不良生长和健康结果之间的关联。随后的研究工作(项目2和项目3)将致力于免疫发育的比较分析:将在玻利维亚、萨摩亚和美国收集的5-20岁儿童样本中比较免疫的多个维度,以深入了解免疫发育的变化范围,并探索比较生态学视角对当前对人类免疫功能的理解的贡献。该项目更广泛的优点包括一些教育倡议:1)开发人类生物学研究的两门课程序列;2)本科生的指导研究经历;3)研究生暑期实验方法研修班;4)在玻利维亚培训国际学生,5)与当地一所高中建立合作关系,为高中生提供实习和研究机会。参与的学生将参与科学过程,将新的方法技能应用于人类生物学和健康问题,并成为合作研究社区的成员。该项目最初是作为职业奖资助的,并于2004年5月转换为工程师和科学家的总统早期职业奖(PECASE)奖。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Thomas McDade其他文献
Prior trauma exposure predicts decoupling of systemic inflammation and somatic symptoms
- DOI:
10.1016/j.bbi.2022.07.138 - 发表时间:
2022-11-01 - 期刊:
- 影响因子:
- 作者:
Joshua Schrock;Robin Nusslock;Thomas McDade;Richard D'Aquila;Brian Mustanski - 通讯作者:
Brian Mustanski
Teacher unfairness in adolescence, educational attainment, and adult Health: The role of school- and individual-level perceptions tested in a national cohort study
青少年时期教师的不公平、教育程度和成人健康:一项全国队列研究中对学校和个人层面认知作用的检验
- DOI:
10.1016/j.ssmph.2025.101810 - 发表时间:
2025-06-01 - 期刊:
- 影响因子:3.100
- 作者:
Shanting Chen;Stephanie Koning;Jessica Polos;Phoebe Lam;Taylor Hargrove;Natalie Ebner;Jacob Aronoff;Thomas McDade - 通讯作者:
Thomas McDade
Invitation for Nominations for 2005
- DOI:
10.1093/jn/134.7.1850 - 发表时间:
2004-07-01 - 期刊:
- 影响因子:
- 作者:
Bettina Shell-Duncan;Thomas McDade - 通讯作者:
Thomas McDade
Thomas McDade的其他文献
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{{ truncateString('Thomas McDade', 18)}}的其他基金
RAPID: Next phase serological testing for SARS-CoV-2 for biocultural research
RAPID:用于生物文化研究的 SARS-CoV-2 下一阶段血清学检测
- 批准号:
2035114 - 财政年份:2020
- 资助金额:
$ 30万 - 项目类别:
Standard Grant
Doctoral Dissertation Research: Investigating the social and developmental determinants of vitamin D production
博士论文研究:调查维生素 D 产生的社会和发展决定因素
- 批准号:
1848357 - 财政年份:2019
- 资助金额:
$ 30万 - 项目类别:
Standard Grant
Doctoral Dissertation Research: Cultural and Social Dimensions of Anti-Mullerian Hormone Screening Technologies
博士论文研究:抗苗勒氏管激素筛查技术的文化和社会维度
- 批准号:
1823543 - 财政年份:2018
- 资助金额:
$ 30万 - 项目类别:
Standard Grant
Early environments, epigenetics, and inflammation during pregnancy
怀孕期间的早期环境、表观遗传学和炎症
- 批准号:
1440564 - 财政年份:2014
- 资助金额:
$ 30万 - 项目类别:
Standard Grant
Ecology of inflammation in lowland Bolivia
玻利维亚低地炎症生态学
- 批准号:
1027687 - 财政年份:2010
- 资助金额:
$ 30万 - 项目类别:
Standard Grant
Doctoral Dissertation Improvement: Market Integration, Stress, and Child Health among the Tsimane' of the Bolivian Amazon
博士论文改进:玻利维亚亚马逊提斯曼人的市场一体化、压力和儿童健康
- 批准号:
0622576 - 财政年份:2006
- 资助金额:
$ 30万 - 项目类别:
Standard Grant
Doctoral Dissertation Research: Social Status and Stress among African American Adolescents
博士论文研究:非裔美国青少年的社会地位和压力
- 批准号:
0514731 - 财政年份:2005
- 资助金额:
$ 30万 - 项目类别:
Standard Grant
Multidimensional Analysis of Quality of Life
生活质量多维分析
- 批准号:
0322380 - 财政年份:2003
- 资助金额:
$ 30万 - 项目类别:
Standard Grant
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