U.S.-Korea Cooperative Research: The Insect Pathogen Xenorhabdus Nematophilus depresses Host Immunity by Inhibiting Eicosanoid Biosynthesis

该项目是关于与韩国研究人员的国际合作，重点是昆虫免疫：昆虫病原体线虫通过抑制二十烷类化合物的生物合成来抑制宿主免疫。昆虫是最成功的动物群体，也是人类唯一的生物竞争者。昆虫对人类的生活和生活质量产生了巨大的经济和公共卫生影响。制定有效和符合环境的昆虫管理战略是必要的。早期的合作研究表明，细菌培养基有机部分中存在的一种细菌因素会抑制细胞免疫反应。本研究旨在确定抑制二十烷类化合物生物合成的细菌因子，并确定该因子对细菌致病作用的影响。

INT-0201376David StanleyUniversity of Nebraska-LincolnlThe project is about international collaboration with researchers in Korea, focusing on insect immunity: The insect pathogen Xenorhabdus nematophilus depresses host immunity by inhibiting eicosanoid biosynthesis. Insects are the most successful group of animals and the only serious biological competitor with humans. Insects exert tremendous economic and public health impacts on human life and life quality. The development of effective and environmentally compatible insect management strategies is necessary. The earlier collaboration study shows that a bacterial factor which is present in the organic fraction of the bacterial culture medium inhibits cellular immune reactions. The proposed study is to identify the bacterial factor responsible for inhibiting eicosanoid biosynthesis and to determine the influence of this factor on bacterial pathogenesis.