U.S.-Korea Cooperative Research: The Insect Pathogen Xenorhabdus Nematophilus depresses Host Immunity by Inhibiting Eicosanoid Biosynthesis

美韩合作研究：昆虫病原体嗜线虫致病杆菌通过抑制类二十烷酸生物合成来抑制宿主免疫力

• 批准号: 0201376
• 负责人: David Stanley
• 金额: $ 1.31万
• 依托单位: University of Nebraska-Lincoln
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-15 至 2005-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0201376&HistoricalAwards=false
• 关键词: U.S.; Korea; Cooperative; Research; Insect

INT-0201376David StanleyUniversity of Nebraska-LincolnlThe project is about international collaboration with researchers in Korea, focusing on insect immunity: The insect pathogen Xenorhabdus nematophilus depresses host immunity by inhibiting eicosanoid biosynthesis. Insects are the most successful group of animals and the only serious biological competitor with humans. Insects exert tremendous economic and public health impacts on human life and life quality. The development of effective and environmentally compatible insect management strategies is necessary. The earlier collaboration study shows that a bacterial factor which is present in the organic fraction of the bacterial culture medium inhibits cellular immune reactions. The proposed study is to identify the bacterial factor responsible for inhibiting eicosanoid biosynthesis and to determine the influence of this factor on bacterial pathogenesis.

INT-0201376 David Stanley内布拉斯加大学林肯分校该项目是关于与韩国研究人员的国际合作，重点是昆虫免疫：昆虫病原体嗜黄杆菌通过抑制类花生酸生物合成来抑制宿主免疫。昆虫是最成功的动物群体，也是唯一与人类竞争的生物。昆虫对人类的生活和生活质量产生巨大的经济和公共卫生影响。必须制定有效和环境相容的昆虫管理战略。早期的合作研究表明，存在于细菌培养基有机部分中的细菌因子抑制细胞免疫反应。拟进行的研究是确定负责抑制类花生酸生物合成的细菌因子，并确定该因子对细菌致病机制的影响。