NIRT: Nanostructural Engineering of Complex Functional Particles

NIRT：复杂功能颗粒的纳米结构工程

• 批准号: 0210835
• 负责人: Timothy Ward
• 金额: $ 162万
• 依托单位: University of New Mexico
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-15 至 2007-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0210835&HistoricalAwards=false
• 关键词: NIRT; Nanostructural; Engineering; Complex; Functional

This four-year Nanoscale Interdisciplinary Research Team (NIRT) project at the University of New Mexico, with Professor Timothy Ward as principal investigator, will investigate the potential to spatially engineer the structure and composition of porous composite nanoparticles with functionalities not previously achieved. The research will focus on particles whose basic scaffolding is a precisely organized inorganic (oxide) nanostructure created by self-assembly of amphiphilic molecules and hydrophilic precursors. The synthesis of silica/surfactant self-assembly will rely on evaporation-induced self-assembly (EISA) within confined environment of an evaporating droplet as opposed to nucleated self-assembly conducted in bulk solution. Using the EISA technique, four general classes of particle architecture, some containing functional components positioned within or at the surfaces of particles, will be investigated. The resultant functionalized nanoparticles and composites could provide a reservoir for sensing or therapeutic agents whose action or delivery is coupled to molecular recognition functionality at the particle surface and is mediated by controlled transfer through nanoporous channels.

新墨西哥大学的这个为期四年的纳米尺度跨学科研究团队(NIRT)项目由蒂莫西·沃德教授担任首席研究员，将研究在空间上设计具有以前未实现的功能的多孔复合纳米颗粒的结构和组成的潜力。这项研究将集中在其基本支架是由两亲性分子和亲水性前体自组装而成的精确组织的无机(氧化物)纳米结构的粒子。二氧化硅/表面活性剂自组装的合成将依赖于蒸发液滴在受限环境中的蒸发诱导自组装(EISA)，而不是在本体溶液中进行的成核自组装。使用EISA技术，将研究四类一般的粒子结构，其中一些包含位于粒子内部或表面的功能组件。由此得到的功能化纳米颗粒和复合材料可以为传感或治疗剂提供储存库，其作用或传递与颗粒表面的分子识别功能相耦合，并通过纳米孔通道的受控转移来介导。